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Complexation of thiacalix[4]arene methylphosphonic and sulphonic acids with amino acids |
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| Authors: | Olga Kalchenko Andriy Drapailo Svetlana Shishkina Oleg Shishkin Sergiy Kharchenko Valery Gorbatchuk |
| Institution: | 1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine , Murmanska str. 5, 02660 , Kyiv , Ukraine oik@ioch.kiev.ua;3. Institute of Organic Chemistry, National Academy of Sciences of Ukraine , Murmanska str. 5, 02660 , Kyiv , Ukraine;4. Institute for Single Crystals, National Academy of Sciences of Ukraine , Lenina Ave, 60, Kharkiv , 61001 , Ukraine;5. Institute for Single Crystals, National Academy of Sciences of Ukraine , Lenina Ave, 60, Kharkiv , 61001 , Ukraine;6. Department of Inorganic Chemistry , V. N. Karazin Kharkiv National University , Svobody sq. 4, Kharkiv , 61122 , Ukraine;7. Kazan Federal University , Kremlyovskaya St., 18, Kazan , 420008 , Russian Federation |
| Abstract: | In this paper, host–guest complexation process of thiacalix4]arene tetrakis–methylphosphonic and tetrakis–sulphonic acids with amino acids by HPLC and molecular modelling methods has been studied. It was shown that thiacalix4]arene tetrakis–methylphosphonic acid due to transformability of macrocyclic skeleton and flexibility of methylphosphonic substituents can adopt its conformation for strong multicentre binding of the amino acids with association constant values 530–10,140 M? 1 in water. |
| Keywords: | thiacalixarene methylphosphonic acids amino acids HPLC X-ray analysis molecular modelling |