The Application of Structure-Activity Relationships (SARs) in the Aquatic Toxicity Evaluation of Discrete Organic Chemicals |
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| Authors: | R G Clements J V Nabholz M G Zeeman C M Auer |
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| Institution: | 1. Environmental Effects Branch (7403), Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency , 401 M. St., S.W., Washington, D.C., 20460-0001, USA;2. Chemical Control Division (7405), Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency , 401 M. St., S.W., Washington, D.C., 20460-0001, USA |
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| Abstract: | Abstract The Office of Pollution Prevention and Toxics (OPPT), United States Environmental Protection Agency (USEPA) routinely uses structure-activity relationships (SAR) for the aquatic hazard assessment of new chemicals submitted under Section 5 of the Toxic Substances Control Act (TSCA). With 15 years of experience and the general acceptance of toxicity predictions based on SARs, OPPT has expanded the use and application of the methodology to include existing chemicals used in printing, dry cleaning, and paint stripping. SAR analysis has also been used in the hazard evaluation of the U.S. and EU/OECD high production volume (HPV) chemicals. This paper describes the assumptions, limitations, and methodology for the use of SARs to evaluate large sets of discrete organic chemicals. |
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| Keywords: | ecotoxicity structure-activity relationships SAR HPV chemical existing chemicals SIDs environmental toxicity |
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