Cu(II)-triggered release of paclitaxel from a supramolecular complex |
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Authors: | Tao Sun Hui Yan Pengyao Xing Jie Su Shangyang Li |
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Institution: | 1. School of Chemistry and Chemical Engineering, Shandong University , Jinan , 250100 , P.R. China;2. Key Laboratory of Colloid and Interface Chemistry of Ministry of Education, Shandong University , Jinan , 250100 , P.R. China;3. College of Chemistry and Chemical Engineering, Liaocheng University , Liaocheng , 252000 , P.R. China |
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Abstract: | The research on the stimuli-responsive property of biological or synthetic macromolecules in a wide range of scientific fields is a crucial subject for the achievements of the targeted drug release and the precise control of the functions of the supramolecules at a molecular level. We used an anthraquinone-functioned cyclodextrin (1) bridged by an aza-arm to solubilise paclitaxel (PTX) by forming a supramolecular complex (1/PTX). The possible inclusion mode was given based on the experimental results of ultraviolet–visible spectroscopy, Fourier transform infrared, X-ray diffraction, fluorescence spectra, nuclear magnetic resonance, transmission electron microscope, scanning electron microscope and dynamic light scattering characterisations. The controlled release of PTX can be achieved by adding Cu2+ to the solution. This study provides useful references in developing stimuli-responsive drug-carrying and drug-releasing materials. |
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Keywords: | controlled release cyclodextrin paclitaxel Cu2+ stimuli-responsive |
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