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Molecular Structure and Affinity to 5-HT1A Receptor of Chlorophenyl(Piperazinylalkyl)Phthalimides |
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| Authors: | Yu M Chumakov Yu A Simonov S G Soboleva V M Sava S A Andronati M Gdaniec |
| Institution: | 1. Institute of Applied Physics, Academy of Sciences of Moldova , 2028, Kishinev, Moldova;2. A. V. Bogatsky Physico-Chemical Institute, Academy of Sciences of Ukraine , Odessa, Ukraine;3. Faculty of Chemistry , A. Mickiewicz University , 60-780, Poznań, Poland |
| Abstract: | Abstract X-ray crystallography, quantum-chemical calculations and conformational analysis have been employed to study chlorophenyl(piperazinylalkyl)phthalimides, potential ligands of 5-HT1A receptor. The molecular recognition of investigated compounds by 5-HT1Aserotonin receptor has been estimated according to their ability to inhibit the 3H8]-DPAT binding. The model for 5-HT1A pharmacophore has been proposed based on crystal structures of N-(aryl)piperazinyl — alkylphthalimides. |
| Keywords: | psychotropic agents chlorophenyl(piperazinylalkyl)phtalimides serotonin receptors affinity pharmacophore |