A case study of solid state inhibition lock opening of pyridine N-oxide in dicarboxylic acid recognition |
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Authors: | Shyamaprosad Goswami Nirmal Kumar Das Debabrata Sen Hoong-Kun Fun |
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Institution: | 1. Department of Chemistry , Bengal Engineering and Science University , Shibpur, Howrah , 711103 , West Bengal , India spgoswamical@hotmail.com;3. Department of Chemistry , Bengal Engineering and Science University , Shibpur, Howrah , 711103 , West Bengal , India;4. X-Ray Crystallography Unit , School of Physics, Universiti Sains Malaysia , 11800 USM, Penang , Malaysia |
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Abstract: | An ethylene-linked mixed pyridine diamide receptor 1 is synthesised to study the binding with dicarboxylic acid in solid phase. In 1H NMR, the amide proton adjacent to pyridine N-oxide shows almost negligible shift, which suggests the non-participation of the amide proton for acid binding in solution. However, in solid phase (X-ray, IR), we have found significant role of this amide proton in binding. |
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Keywords: | dicarboxylic acid recognition lock opening pyridine N-oxide amide supramolecular architecture |
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