Investigation of the complexation of essential oil components with cyclodextrins |
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| Authors: | Miriana Kfoury Ramona Balan David Landy Denisa Nistor |
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| Institution: | 1. Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), ULCO, F-59140 Dunkerque, France;2. Bioactive Molecules Research Group, Department of Chemistry and Biochemistry, Faculty of Sciences-2, Doctoral School of Science and Technology, Lebanese University, Fanar, Lebanon;3. Department of Chemical and Food Engineering, University Vasile Alecsandri, 600115 Bacau, Roumania |
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| Abstract: | The formation of inclusion complexes of six essential oil (EO) components (β-caryophyllene, cis-ocimene, trans-ocimene, sabinene hydrate (thujanol), γ-terpinene and α-terpineol) with six cyclodextrins (CDs) (α-CD, β-CD, γ-CD, HP-β-CD, RAMEB and CRYSMEB) was investigated by using static headspace-gas chromatography and UV–visible spectroscopy. Retention studies showed that CDs could efficiently reduce the volatility of EO components except for β-caryophyllene with α-CD. In this case, no inclusion complex was detected while for other compounds the formation of 1:1 inclusion complexes was observed. Results revealed that the inclusion stability mainly depends on geometric complementarity between encapsulated molecule and CD's cavity. Molecular modelling was used to investigate the complementarities between host and guest. Thus, CDs could efficiently be regarded as promising encapsulants for EO components leading to improve their application in cosmetic, pharmaceutical and agriculture fields. |
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| Keywords: | cyclodextrins essential oils formation constant molecular modelling retention |
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