Synthesis of 1,3-{Di-[N-bis(dimethylamino)methane]}- benzyl-diamide and its Molecular Recognition of Nucleotides in Aqueous Solution |
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| Authors: | Haoxiang Gao Liping Cai Yanxing Qi Hanqing Wang |
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| Institution: | 1. Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , 730000, Lanzhou, People's Republic of China;2. National Laboratory of Applied Organic Chemistry and Department of Chemistry , Lanzhou University , 730000, Lanzhou, People's Republic of China |
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| Abstract: | 1,3-Di-{N-bis(dimethylamino)methane]}benzyl-diamide 1 was synthesized by the reaction of isophthaloyl dichloride with 1,1,3,3-tetramethylguanidine (TMG). Its structure was confirmed by IR, 1H NMR, EI-MS and elemental analysis. 1H NMR results of the interaction of 1 with phosphate-containing biomolecules showed it has the ability of selective molecular recognition for nucleotides. |
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| Keywords: | Guanidine derivative Nucleotides Molecular recognition H NMR |
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