Cucurbit[5]uril derivatives as oxygen carriers |
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Authors: | Gaspard Huber Patrick Berthault Anvi Laetitia Nguyen Alain Pruvost Elodie Barruet Julie Rivollier |
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Affiliation: | 1. NIMBE, CEA, CNRS, Université Paris-Saclay, CEA Saclay, Gif-sur-Yvette, Francegaspard.huber@cea.frhttps://orcid.org/0000-0001-5766-1916;3. NIMBE, CEA, CNRS, Université Paris-Saclay, CEA Saclay, Gif-sur-Yvette, Francehttps://orcid.org/0000-0003-4008-2912;4. SPI, Plateforme SMArt-MS, CEA, INRA, Université Paris-Saclay, Gif-sur-Yvette, France;5. SPI, Plateforme SMArt-MS, CEA, INRA, Université Paris-Saclay, Gif-sur-Yvette, Francehttps://orcid.org/0000-0002-7781-7735;6. NIMBE, CEA, CNRS, Université Paris-Saclay, CEA Saclay, Gif-sur-Yvette, France;7. SCBM, Joliot, CEA, Université Paris-Saclay, Gif-sur-Yvette, France |
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Abstract: | ABSTRACTCucurbit[n]urils are rigid cage-molecules of pumpkin-like shape, made of n-glycoluril units, able to bind mainly neutral molecules and cations. In this work, we investigate the binding of three cucurbit[5]uril derivatives with dioxygen O2 and show that one of them, namely per-hydroxylated cucurbit[5]uril, (OH)10CB[5], is able to significantly bind dioxygen gas at physiological temperature, even in the presence of sodium chloride at the concentration of injectable solution in blood. As cucurbit[n]urils studied up to now reveal low toxicity, per-hydroxylated cucurbit[5]uril appears as a promising precursor to design a host able to transport O2 in a haemoglobin substitute solution. |
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Keywords: | Cucurbituril dissolved gas binding supramolecular chemistry oxygen carrier |
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