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| Regioselective 1,2-Addition of Ti(IV)-enolate to α, β–Unsaturated Compounds | |
| 作者姓名： | Gui Sheng DENG Ming Yi LIAO Xue TIAN Jian Bo WANG Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry Peking University Beijing 100871 |
| 作者单位： | Gui Sheng DENG，Ming Yi LIAO，Xue TIAN，Jian Bo WANG Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education，College of Chemistry，Peking University，Beijing 100871 |
| 摘 要： | The nucleophilic addition to α, β-unsaturated carbonyl compounds is a fundamental C-C bond forming reaction in organic chemistry1. Since there are two reaction sites in the α, β–unsaturated carbonyl group, the regioselectivity of the nucleophilic addition (1, 2 vs. 1, 4 addition) is of primary importance when applying this type of reaction in organic synthesis. Factors that control the regioselectivity include the softness and hardness of the attacking nucleophiles2, solvent and temperatu… |
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