Sesquiterpenoids from Curcuma wenyujin dreg and their biological activities |
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| Authors: | Hui-Feng Huang Cai-Juan Zheng Guang-Ying Chen Wen-Qing Yin Xian Huang Zheng-Rong Mo |
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| Institution: | a Key Laboratory of Tropical Medicinal Plant Chemistry, the Ministry of Education of China, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China;
b Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, the Ministry of Education of China, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, China;
c Hainan Bikai Pharmaceutical Co., Ltd., Haikou 570216, China |
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| Abstract: | Four new sesquiterpenoids, 4,8-dioxo-6β-hydroxyl-7β,11-epoxycarabrane (1), 4,8-dioxo-6β-hydroxyl-7α,11-epoxycarabrane (2), wenyujinins Q and R (3-4), and nine known sesquiterpenoids (5-13) were isolated from the Curcuma wenyujin (C. wenyujin) dreg. Their structures and relative configurations were elucidated using 1D, 2D NMR, and HR-ESI-MS data. All the compounds were isolated for the first time from the C. wenyujin dreg and evaluated for their antibacterial and antifungal activities. Compounds 3, 5-8 exhibited strong broad-spectrum antifungal activities against tested nine pathogenic fungi. |
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| Keywords: | Curcuma wenyujin dreg Sesquiterpenoids Antibacterial activity Antifungal activity |
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