C60(OH)n-loaded nanofibrous membranes protect HaCaT cells from ROS-associated damage |
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| Authors: | Mengyu Guo Shuying Bi Jing Liu Wenshi Xu Guoqiang Zhou Ying Liu Chunying Chen |
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| Affiliation: | a CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China;b Chinese PLA Air Force General Hospital, Beijing 100142, China;c Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China |
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| Abstract: | Environmental stress factors could lead to the excess generation of reactive oxygen species (ROS) that induces various forms of skin damage related to oxidative stress. Polyhydroxylated fullerene derivative C60(OH)n, acting as an effective agent for prevention of skin aging, is widely used in the lotion and sunscreens in the field of cosmetics, but rarely used in the masks. In this study, we prepared C60(OH)n loaded nanofibrous membranes to protect human keratinocyte cells from ROS-associated damage and suppress the elevation of intracellular ROS and Ca2+ along with the apoptotic cell death. Two FDAapproved biodegradable polymers, PLGA and PCL, have been used for making the electrospun nanofibers, with C60(OH)n added to the polymers as an antioxidant. The nanofibrous membranes with good biocompatibility might be potentially applied in clinical practice to reduce skin aging. |
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| Keywords: | C60(OH)n Electrospining Nanofibrous membranes ROS Skin damage |
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