Triterpenoids and phenolics from the fruiting bodies of Inonotus hispidus and their activations of melanogenesis and tyrosinase |
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| Authors: | Qing Ren Xue-Ying Lu Jian-Xin Han Haji Akber Aisa Tao Yuan |
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| Affiliation: | a The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Chinese Academy of Sciences, State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China;b University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Two new 24-methyl lanostane triterpenoids, hispindic acids A and B (1 and 2), and a new phenolic compound, hispinine (7), along with nine known compounds (3-6, and 8-12), were isolated from the fruiting bodies of Inonotus hispidus. Their structures were elucidated based on the extensive analysis of spectroscopic data (NMR and HRMS). Hispindic acid A (1) possesses an unusual formyl group at C-30. Compounds 1, 3-4, and 8 showed stronger activate abilities of melanogenesis and tyrosinase in B16 melanoma cells than those of positive control, 8-methoxypsoralen, at 50 μmol/L. |
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| Keywords: | Inonotus hispidus Lanostane triterpenoids Phenolic compound Melanogenesis Tyrosinase |
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