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Cytotoxic cassane diterpenoids from the seeds of Caesalpinia sappan |
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| Authors: | Zheng-Feng Wu Han Bao Fa-Yang Zhou Jing-Xin Liu Fan-Cheng Meng Lu Feng Jin-Jian Lu Qing-Wen Zhang Yang Ye Li-Gen Lin |
| Institution: | a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China; b State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhangjiang Hi-Tech Park, Shanghai 201203, China |
| Abstract: | Phytochemical investigation on the seeds of Caesalpinia sappan led to the isolation of five new cassanetype diterpenoids, named 11-oxo-phanginin A (1), caesalsappanins O-Q (2-4) and phanginin U (5), together with five known compounds. The structures of the new compounds were elucidated by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. All the new compounds showed moderate cytotoxic effects on human breast cancer MCF-7 and human colon cancer HCT116 cell lines. |
| Keywords: | Caesalpinia sappan Cassane diterpenoid Phanginin Caesalsappanin Cytotoxicity |
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