Three-component reaction of triphenylphosphine,dialkyl but-2-ynedioate and arylidene pivaloylacetonitrile for diastereoselective synthesis of densely substituted 2,3-dihydrofurans |
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| Authors: | Wen-Jie Qi Ying Han Chang-Zhou Liu Chao-Guo Yan |
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| Affiliation: | College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China |
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| Abstract: | The three-component reaction of triphenylphosphine, dialkyl but-2-ynedioate and arylidene pivaloylacetonitrile in dry methylene dichloride at room temperature resulted in unexpected densely substituted 1-(triphenyl-λ5-phosphanylidene)ethyl)-2,3-dihydrofurans in satisfactory yields with high diastereoselectivity. The relative configuration of the 2,3-dihydrofurans was elucidated by determination of single crystal structures. |
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| Keywords: | Multicomponent reaction Triphenylphosphine But-2-ynedioate Pivaloylacetonitrile 2 3-Dihydrofuran |
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