Effects of concave and convex substrate curvature on cell mechanics and the cytoskeleton |
| |
Authors: | Shuang-Shuang Chen Xue-Min Lu Qing-Hua Lu |
| |
Institution: | School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China |
| |
Abstract: | In order to understand how cells respond to concave and convex subcellular surface structures,colloidal crystal array and honeycomb-structured surfaces composed of highly ordered hexagonal units with completely inverse curvature were fabricated via facile self-assembly and breath figure approaches, respectively.The influence of hexagonal surface curvature on cell fate was subsequently investigated. Cells underwent more extensive spreading on the convex colloidal crystal array surface,while adhesive forces were higher on the concave honeycomb surface.The behaviors of cells on the different surfaces were investigated by comparing cell morphology,cellular adhesive force and cytoskeleton structure.The results revealed comprehensive differences in cell behavior between those on concave honeycomb surfaces and convex colloidal crystal arrays. |
| |
Keywords: | Colloidal crystal array Honeycomb structure Substrate curvature Cytoskeleton Adhesive force |
本文献已被 CNKI 等数据库收录! |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
| 点击此处可从《中国化学快报》下载免费的PDF全文 |
|