| Base mediated direct C–H amination for pyrimidines synthesis from amidines and cinnamaldehydes using oxygen as green oxidants |
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| 作者姓名： | Wei Guo |
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| 作者单位： | a School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China;
b Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China |
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| 基金项目： | We are grateful to the China Postdoctoral Science Foundation Funded Project(No. 2014M562165), Jiangxi Natural Science Foundation(Nos. 20133BCB24011, 20141BBG70070 and 20151BAB203011) and the Science Foundation of Jiangxi Provincial Department of Education(No. Gjj4669) for support of this research. |
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| 摘 要： | A direct metal-free C–H amination reaction of cinnamaldehydes and amidines to realize the synthesis of polysubstituted pyrimidines was developed in the presence of base. This greener synthetic methodology provides a straightforward approach to the synthesis of a variety of pyrimidine derivatives under mild reaction condition using oxygen as sole oxidants.
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Base mediated direct C-H amination for pyrimidines synthesis from amidines and cinnamaldehydes using oxygen as green oxidants |
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| Wei Guo.Base mediated direct C-H amination for pyrimidines synthesis from amidines and cinnamaldehydes using oxygen as green oxidants[J].Chinese Chemical Letters,2016,27(1):47-50. |
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| Authors: | Wei Guo |
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| Institution: | a School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China;
b Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China |
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| Abstract: | A direct metal-free C-H amination reaction of cinnamaldehydes and amidines to realize the synthesis of polysubstituted pyrimidines was developed in the presence of base. This greener synthetic methodology provides a straightforward approach to the synthesis of a variety of pyrimidine derivatives under mild reaction condition using oxygen as sole oxidants. |
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| Keywords: | C-H amination Pyrimidines Amidines Cinnamaldehydes Oxygen |
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