Naphthalimide-modified near-infrared cyanine dye with a large stokes shift and its application in bioimaging |
| |
Authors: | Di Wu Yuanzhi Shen Jianhua Chen Guotao Liu Haiyan Chen Jun Yin |
| |
Institution: | a Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China;
b Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China |
| |
Abstract: | Developing the novel fluorescent dyes with a larger Stokes shift is still a challenge in the research of fluorescence probes. In this work, a naphthalimide-modified near-infrared cyanine dye with an emission at 785 nm has been synthesized for lysosome-targeting imaging. This fluorescent dye showed a large Stokes shift (up to 165 nm) and favorable lysosome-targeting property, which facilitated it to be a potential candidate for studying of lysosomal functions. The result also indicated that the probe is a promising contrast agent for in vivo imaging in mouse models. |
| |
Keywords: | Cyanine Naphthalimide Near-infrared Stokes shift Bioimaging |
本文献已被 CNKI 等数据库收录! |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
| 点击此处可从《中国化学快报》下载免费的PDF全文 |
|