Palcernuine,the first [5/6/6/6]-cernuane-type alkaloid from Palhinhaea cernua f. sikkimensis |
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| Authors: | Yu Tang Juan Xiong Yike Zou Bastien Nay Li-Jun Wang Jin-Feng Hu |
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| Institution: | a Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China;
b Department of Chemistry, University of Pennsylvania, Philadelphia 19104-6323, USA;
c Unité Molécules de Communication et Adaptation des Micro-organismes, Sorbonne Universités, Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique (CNRS UMR 7245), Paris 75005, France |
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| Abstract: | One novel (named palcernuine, 1) and five known cernuane-type (2-6) alkaloids were isolated from the whole plant of Palhinhaea cernua f. sikkimensis. The structure of 1, possessing an unprecedented 5/6/6/6]-tetracyclic ring system containing two nitrogen atoms, was established on the basis of spectroscopic methods, and its absolute configuration was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. A plausible biosynthetic pathway to 1 is proposed. |
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| Keywords: | Palhinhaea cernua f sikkimensis Lycopodiaceae Palcernuine Cernuane-type alkaloids Biosynthetic pathway |
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