A catalyst-and solvent-free multicomponent synthesis of 7-azagramine analogues via a Mannich type reaction |
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| Authors: | Sakharam B. Dongare Hemant V. Chavan Pravin S. Bhale Yoginath B. Mule Amol S. Kotmale Babasaheb P. Bandgar |
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| Affiliation: | a School of Chemical Sciences, Solapur University, Solapur 413 255, Maharashtra, India;b Department of Chemistry, A. S. P. College, Devrukh, Dist-Ratnagiri 415 804, Maharashtra, India |
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| Abstract: | A catalyst-and solvent-free protocol for the synthesis of 7-azagramine analogues is described via a three-component Mannich type reaction between 7-azaindole, aromatic aldehydes and heterocyclic amines in acceptable to excellent yields. Structures of the compounds were confirmed satisfactorily by 1H NMR, IR, mass, TOCSY, HSQC and HMBC spectral analyses. |
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| Keywords: | Bioisosters 7-Azaindole Mannich reaction Multicomponent reaction |
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