Concise synthesis of 1-epi-castanospermine |
| |
| Authors: | Bin Cheng Yi-Xian Li Yue-Mei Jia Chu-Yi Yu |
| |
| Affiliation: | a Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;b University of Chinese Academy of Sciences, Beijing 100049, China;c National Engineering Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, China |
| |
| Abstract: | 1-epi-Castanospermine (5) was synthesized from readily available 2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin (11) in 9 steps and 21% overall yield, with selective debenzylation, Barbier reaction and reductive amination as the main reaction steps. |
| |
| Keywords: | Reductive amination Synthesis Alkaloids Glycosidase inhibitors Polyhydroxylated indolizidines |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
|
点击此处可从《中国化学快报》下载全文 |
|
