A 1,8-naphthalimide-derived turn-on fluorescent probe for imaging lysosomal nitric oxide in living cells |
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| Authors: | Wei Feng Qing-Long Qiao Shuang Leng Lu Miao Wen-Ting Yin Li-Qiu Wang Zhao-Chao Xu |
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| Institution: | a College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, China;
b State Key Laboratory of Fine Chemicals, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;
c State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China |
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| Abstract: | Nitric oxide has played an important role in many physiological and pathological processes as a kind of important gas signal molecules. In this work, a new fluorescent probe LysoNO-Naph for detecting NO in lysosomes based on 1,8-naphthalimide was reported. LysoNO-Naph has sub-groups of o-phenylenediamine as a NO reaction site and 4-(2-aminoethyl)-morpholine as a lysosome-targetable group. This probe exhibited good selectivity and high sensitivity (4.57 μmol/L) toward NO in a wide pH range from 4 to 12. Furthermore, LysoNO-Naph can be used for imaging NO in lysosomes in living cells. |
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| Keywords: | Fluorescent probe Nitric oxide Lysosome localized Imaging in living cells |
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