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PEGylated BODIPY assembling fluorescent nanoparticles for photodynamic therapy |
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| Authors: | Yu Zhu Wenhai Lin Wei Zhang Yuqin Feng Zhineng Wu Li Chen Zhigang Xie |
| Affiliation: | a Department of Chemistry, Northeast Normal University, Changchun 130024, China;b State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;c University of Chinese Academy of Sciences, Beijing 100049, China;d College of Materials Science andEngineering, Jilin University, Changchun 130024, China |
| Abstract: | Two amphiphilic macromolecules were synthesized from polyethylene glycol monomethylether (PEG) and borondipyrrolmethene (BODIPY) via one-pot multicomponent Passerini reaction, and they could self-assemble into stable nanoparticles (NPs) in aqueous media. The optical properties, including fluorescence resonance energy transfer (FRET) were studied in detail. The obtained NPs possess good cytocompatibility, and could be used for living cell imaging and effective photodynamic therapy (PDT). These results shed light on one-pot synthesis of PEGylated fluorescent nanoparticles via multicomponent reaction for biomedical application. |
| Keywords: | Multicomponent Passerini reaction Fluorescent nanoparticles BODIPY Cellular imaging Photodynamic therapy |
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