Preparation and drug release property of CO2 stimulus-sensitive poly(N, N-dimethylaminoethyl methacrylate)-b-polystyrene nanoparticles |
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| Authors: | Xiaohong Wang Guohua JiangZhen Wei Xia LiBolin Tang |
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| Institution: | Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education, Zhejiang Sci-Tech University, Hangzhou 310018, PR China; Department of Materials Engineering, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, PR China |
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| Abstract: | The CO2 stimulus-sensitive nanoparticles based on poly(N, N-dimethylaminoethyl methacrylate)-b-poly styrene (PDMAEMA-b-PS) were prepared via surfactant-free miniemulsion reversible addition–fragmentation chain transfer (RAFT) polymerization. The as-prepared nanoparticles exhibited core–shell structure with about 120 nm in diameter. Their dispersion/aggregation in water can be adjusted by alternatively bubbling of CO2 and N2. Drug release from these nanoparticles can be accelerated (or delayed) by bubbling (or removing) of CO2. |
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| Keywords: | Miniemulsion RAFT polymerization CO2 stimulus-sensitive Nanoparticles Drug release |
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