Synthesis of 3,4-disubstituted 2H-benzopyrans through C-C bond formation via electrophilic cyclization |
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Authors: | Worlikar Shilpa A Kesharwani Tanay Yao Tuanli Larock Richard C |
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Affiliation: | Department of Chemistry, Iowa State University, Ames, IA 50011, USA. |
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Abstract: | The electrophilic cyclization of substituted propargylic aryl ethers by I2, ICl, and PhSeBr produces 3,4-disubstituted 2H-benzopyrans in excellent yields. This methodology results in vinylic halides or selenides under mild reaction conditions and tolerates a variety of functional groups, including methoxy, alcohol, aldehyde, and nitro groups. |
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