Poly(ether imide) membranes modified with poly(ethylene imine) as potential carriers for epidermal substitutes |
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Authors: | Trimpert Christiane Boese Gregor Albrecht Wolfgang Richau Klaus Weigel Thomas Lendlein Andreas Groth Thomas |
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Affiliation: | GKSS Research Centre, Institute of Polymer Research, Kantstrasse 55, D-14513 Teltow, Germany. |
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Abstract: | Poly(ether imide) (PEI) membranes were modified with a linear low-molecular weight (PETIM_0.6) and a branched high-molecular weight poly(ethylene imine) (PETIM_60). The membrane surfaces became more hydrophilic and the zeta potentials were shifted from negative to positive zeta values after immobilisation of both PETIM. These measurements also indicated the presence of a swollen surface layer in the case of PETIM_60, while a regular structuring of the surface was observed with scanning force microscopy for PETIM_0.6. A human keratinocyte cell line HaCaT was cultured on the different membranes. It was found that HaCaT cell growth was stimulated by PETIM_0.6. Cells reached earlier confluence on this substratum, while their growth was inhibited on a PEI membrane modified with PETIM_60, which makes PEI membranes modified with PETIM_0.6 a promising material for in vitro culture of epidermal transplants. |
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Keywords: | biomaterials functionalization of polymers keratinocytes poly(ether imide) poly(ethylene imine) polymer membrane |
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