Super silyl group for a sequential diastereoselective aldol-polyhalomethyllithium addition reaction |
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| Authors: | Boxer Matthew B Yamamoto Hisashi |
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| Institution: | Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA. |
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| Abstract: | The super silyl group governs high diastereoselectivity and yields for a sequential aldol-polyhalomethyllithium addition reaction. This unique silyl group is necessary to obtain the diastereoselectivities associated with this sequential reaction, capable of generating two new stereocenters. Alpha-polyhalomethylcarbinols are generated with the simple and inexpensive dihalomethanes and trihalomethanes. |
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