Synthesis and unusual beckmann fragmentation reaction of syn-3-Methoxy-6α,17β-Dihydroxyestra-1,3,5(10)-trien-7-one oxime |
| |
Authors: | Vjera M Pejanovic Julijana A Petrovt Jnos J Csandi Slobodanka M Stankovi Duan A Miljkovic |
| |
Institution: | Vjera M. Pejanovic, Julijana A. Petrovtć, János J. Csanádi, Slobodanka M. Stanković,Dušan A. Miljkovic |
| |
Abstract: | Sodium borohydride reduction of anti-3-methoxy-17β-hydroxyestra-1,3,5(10)-trien-6,7-dione 7-oxime (4a) afforded syn-3-methoxy-6α,17β-dihydroxyestra-1,3,5(10)-trien-7-one oxime (5), which in thionyl chloride at −18 °C undenvent Beckmann fragmentation reaction to the unexpected 3-methoxy-6-oxo-17β-hydroxy-6.7-secoestra-1.3.5(10)-trien-7-nitrile (6). A mechanism of this fragmentation process was proposed. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|