An experimental study of chromatographic dynamics in open and packed non-cylindrical conduits |
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Authors: | Rozing Gerard van de Goor Tom Yin Hongfeng Killeen Kevin Glatz Bernd Kraiczek Karsten Lauer Henk H |
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Institution: | Agilent Technologies Inc, Palo Alto, CA, USA. gerard_rozing@agilent.com |
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Abstract: | A systematic investigation of the influence of the perimeter shape of open and particle packed fused silica capillaries on chromatographic properties such as resistance to flow and dispersion of solutes propelled through these channels has been conducted. Verifications of these uncommon experiments with existing theoretical treatments are presented and the insights transferred to a novel polymer chip design with integrated facilities for complex separations. A comparison of the chromatographic performance of a real life proteomics sample on this chip with a capillary column of "similar" dimensions is presented. |
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