Microwave-accelerated SPOT-synthesis on cellulose supports |
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| Authors: | Bowman Matthew D Jeske Ryan C Blackwell Helen E |
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| Institution: | Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706-1322, USA. |
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| Abstract: | reaction: see text] We demonstrate that microwave irradiation can dramatically accelerate reaction rates for spatially addressable library synthesis on planar membrane supports. The development of a robust support/linker system, microwave-assisted synthesis of small molecule test libraries, and methods for solid-phase scale-up on cellulose are described. |
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