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Interplay between the Ribosomal Tunnel,Nascent Chain,and Macrolides Influences Drug Inhibition

Authors:	Agata L Starosta Viktoriya V Karpenko Anna V Shishkina Aleksandra Mikolajka Natalia V Sumbatyan Frank Schluenzen Galina A Korshunova Alexey A Bogdanov Daniel N Wilson

Institution:	1. Gene Center and Department of Biochemistry, University of Munich, LMU, Munich D-81377, Germany;2. Center for Integrated Protein Science Munich, University of Munich, LMU, Munich D-81377, Germany;3. Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow 119992, Russia;4. A.N. Belozersky Institute of Physico-Chemical Biology,, M.V. Lomonosov Moscow State University, Moscow 119992, Russia;5. Deutsches Elektronen-Synchrotron, Hamburg D-22603, Germany

Abstract:	Download : Download high-res image (181KB) Download : Download full-size image Highlights? Macrolides exhibit nascent polypeptide chain–dependent inhibition ? Peptides can form specific interactions with the ribosomal tunnel ? A covalent bond between tylosin and the ribosome is necessary for inhibitory activity

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