| 含1,2,4-三唑杂环的新型Strobilurins衍生物的合成及杀菌活性 |
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| 引用本文： | 赵培亮,章博,王亚洲,杨光富. 含1,2,4-三唑杂环的新型Strobilurins衍生物的合成及杀菌活性[J]. 有机化学, 2008, 28(5): 875-880 |
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| 作者姓名： | 赵培亮 章博 王亚洲 杨光富 |
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| 作者单位： | 华中师范大学化学学院农药与化学生物学教育部重点实验室,武汉,430079 |
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| 基金项目： | 国家自然科学基金，教育部跨世纪优秀人才培养计划，教育部科学技术研究项目，湖北省优秀中青年科技创新团队资助项目 |
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| 摘 要： | 为了寻找新的高活性先导化合物, 设计合成了14个未见文献报道的Strobilurins类衍生物, 结构经MS, 1H NMR, 元素分析确认. 并用X-ray单晶衍射测定了(E)-3-甲氧基-2-[(5-甲基-4-邻溴代苯亚甲基亚胺基-1,2,4-三唑)-3-硫亚甲基]-苯基丙烯酸甲酯(5i)的晶体结构, 证实了分子中的两个C＝C均为E-式构型. 初步生物活性测试结果表明, 在实验浓度下部分化合物具有一定的杀菌活性.
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| 关 键 词： | Strobilurins 杀菌活性 晶体结构 |
| 收稿时间： | 2007-09-12 |
| 修稿时间： | 2007-10-15 |
Synthesis and Fungicidal Activities of Novel Analogues of Strobilurins Containing 1,2,4-Triazol Moiety |
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| ZHAO,Pei-Liang,ZHANG,Bo,WANG,Ya-Zhou,YANG,Guang-Fu. Synthesis and Fungicidal Activities of Novel Analogues of Strobilurins Containing 1,2,4-Triazol Moiety[J]. Chinese Journal of Organic Chemistry, 2008, 28(5): 875-880 |
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| Authors: | ZHAO Pei-Liang ZHANG Bo WANG Ya-Zhou YANG Guang-Fu |
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| Affiliation: | (Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079) |
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| Abstract: | In order to find highly active lead compounds, fourteen novel derivatives of strobilurins were designed and synthesized. Their structures were characterized by MS, 1H NMR spectra and elemental analy-sis. The single crystal structure of compound 5i was determined by X-ray diffraction analysis, which revealed that the two carbon-carbon double bonds in the molecule were of E,E-configurations. The preliminary bioassay showed that some of them exhibited certain fungicidal activities. |
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| Keywords: | Strobilurins |
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