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One‐Pot,Three‐Component Condensation of Aldehydes, 2‐Naphthol and 1,3‐Dicarbonyl Compounds
Authors:Li‐Ping Mo  Hong‐Li Chen
Abstract:A practical and efficient procedure for the one‐pot multicomponent couping of aryl aldehydes, 2‐naphthol and cyclic 1,3‐dicarbonyl compounds using perchloric acid adsorbed on silica gel (HClO4‐SiO2) as a highly efficient, inexpensive, convenient, reusable heterogeneous catalyst under solvent‐free conditions has been developed. Various biologically important 12‐aryl‐8,9,10,12‐tetrahydrobenzoa]xanthen‐11‐one derivatives have been efficiently synthesized in high to excellent yields. The present approach offers several advantages such as shorter reaction times, simple work‐up, excellent yields, low cost, and mild reaction conditions. Furthermore, the catalyst can be recovered simply and reused without appreciable loss of its catalytic activity.
Keywords:Xanthene  Multi‐component reaction  2‐Naphthol  Aldehyde  Heterogeneous catalyst  HClO4‐SiO2
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