Tailoring photosensitive ROS for advanced photodynamic therapy |
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| Authors: | Duc Loc Sai Jieun Lee Duc Long Nguyen Young-Pil Kim |
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| Institution: | 1.Department of Life Science, Hanyang University, Seoul, 04763 Republic of Korea ;2.Department of HY-KIST Bio-Convergence, Hanyang University, Seoul, 04763 Republic of Korea ;3.Research Institute for Natural Sciences, Hanyang University, Seoul, 04763 Republic of Korea ;4.Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul, 04763 Republic of Korea ;5.Institute of Nano Science and Technology, Hanyang University, Seoul, 04763 Republic of Korea |
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| Abstract: | Photodynamic therapy (PDT) has been considered a noninvasive and cost-effective modality for tumor treatment. However, the complexity of tumor microenvironments poses challenges to the implementation of traditional PDT. Here, we review recent advances in PDT to resolve the current problems. Major breakthroughs in PDTs are enabling significant progress in molecular medicine and are interconnected with innovative strategies based on smart bio/nanomaterials or therapeutic insights. We focus on newly developed PDT strategies designed by tailoring photosensitive reactive oxygen species generation, which include the use of proteinaceous photosensitizers, self-illumination, or oxygen-independent approaches. While these updated PDT platforms are expected to enable major advances in cancer treatment, addressing future challenges related to biosafety and target specificity is discussed throughout as a necessary goal to expand the usefulness of PDT.Subject terms: Biological therapy, Biosensors |
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