New Sphingolipids and Other Constituents of Pancovia laurentii |
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Authors: | Ferdinand Tantangmo,Bruno Ndjakou Lenta,Silvè re Ngouela,Louis Marie Kamdem,Bernard Weniger,Etienne Tsamo,Annelise Lobstein,Catherine Vonthron‐Sé né cheau |
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Abstract: | Phytochemical investigation of the bark and leaves of Pancovia laurentii (Sapindaceae) resulted in the isolation of a new ceramide and a new cerebroside, named pancoviamide ( 1 ), and pancovioside ( 2 ) respectively, together with six known compounds: uracil, (R)‐N‐[(1S,2S,3R)‐2,3‐dihydroxy‐1‐(hydroxymethyl)heptadec‐5‐en‐1‐yl]‐2‐hydroxytetracosanamide, stigmasta‐7,22‐dien‐3‐ol, β‐stitosterol, β‐sitosterol 3‐O‐β‐D ‐glucopyranoside, and 2,3‐dihydroxypropyl pentadecanoate. The structures of 1 and 2 were determined by means of spectroscopic methods. Compounds 1 and 2 were tested in vitro for their antiprotozoal properties against several protozoa and for their cytotoxicity. |
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Keywords: | Pancovia laurentii Sphingolipids Pancoviamide Pancovioside Antiprotozoal activity Cytotoxic activity |
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