Synthetic efforts toward the macrolactone core of Leucascandrolide A |
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| Authors: | Ferrié Laurent Boulard Lucie Pradaux Fabienne Bouzbouz Samir Reymond Sébastien Capdevielle Patrice Cossy Janine |
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| Affiliation: | Laboratoire de Chimie Organique, ESPCI, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France. |
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| Abstract: | A chemoselective synthesis of 1, the macrocyclic core of leucascandrolide A, has been achieved by utilizing highly enantioselective allylmetalations, an enantioselective Noyori reduction of a propargylic ketone, and olefin metatheses as the key steps. |
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