Enantioselective aza-Michael reaction of hydrazide to chalcones through the nonactivated amine moiety conjugated addition |
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| Authors: | Jiang Jun Cai Yunfei Chen Weiliang Lin Lili Liu Xiaohua Feng Xiaoming |
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| Affiliation: | Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China. |
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| Abstract: | The catalytic asymmetric aza-Michael reaction of benzoyl hydrazine toward chalcones through the nonactivated amine moiety conjugated addition was facilitated by the developed N,N'-dioxide-Sc(OTf)(3) complex under mild conditions, affording the pharmacologically and synthetically useful products in moderate to high yields with up to 97% ee. |
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