Catalytic asymmetric addition of dimethylzinc to alpha-ketoesters, using mandelamides as ligands |
| |
Authors: | Blay Gonzalo Fernandez Isabel Marco-Aleixandre Alícia Pedro José R |
| |
Affiliation: | Departament de Química Orgànica, Facultat de Química, Universitat de València, Dr. Moliner, 50, E-46100-Burjassot, Spain. |
| |
Abstract: | [reaction: see text] A strategy based on the control of the electron-donating capabilities of the coordinating groups of the ligand has been applied in the catalytic asymmetric addition of organometallic reagents to ketoesters. Mandelamides having deprotonated alcohol and carboxyamido groups catalyzed the addition of dimethylzinc to alpha-ketoesters with good yields and ee (up to 90%). |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|