| 一种新的合成12-氧代-1,15-十五内酰胺的方法 |
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| 引用本文： | 侯传金,梁晓梅,吴景平,田美玲,王道全.一种新的合成12-氧代-1,15-十五内酰胺的方法[J].有机化学,2006,26(11):1597-1599. |
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| 作者姓名： | 侯传金 梁晓梅 吴景平 田美玲 王道全 |
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| 作者单位： | 中国农业大学应用化学系,农业部农药化学与应用技术重点开放实验室,北京,100094 |
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| 基金项目： | 国家“十五”科技公关计划(No．2004BA30823-15)资助项目． |
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| 摘 要： | 设计了一种新的合成12-氧代-1,15-十五内酰胺(4)的方法, 即以α-硝基环十二酮(1)为原料, 经与丙烯腈的Michael加成, 氰基选择性还原为氨基后扩环, 再经Nef反应合成了4, 总收率为28%.
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| 关 键 词： | 12-氧代-1 15-十五内酰胺 Michael加成 扩环 Nef反应 |
| 收稿时间： | 03 14 2006 12:00AM |
| 修稿时间： | 05 29 2006 12:00AM |
A Novel Synthesis of 12-Oxo-1,15-pentadecanlactam |
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| HOU,Chuan-Jin,LIANG,Xiao-Mei,WU,Jing-Ping,TIAN,Mei-Ling,WANG,Dao-Quan.A Novel Synthesis of 12-Oxo-1,15-pentadecanlactam[J].Chinese Journal of Organic Chemistry,2006,26(11):1597-1599. |
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| Authors: | HOU Chuan-Jin LIANG Xiao-Mei WU Jing-Ping TIAN Mei-Ling WANG Dao-Quan |
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| Institution: | Key Laboratory of Pesticide Chemistry and Application Technology, Department of Applied Chemistry, China Agricultural University, Beijing 100094 |
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| Abstract: | A new procedure for the synthesis of 12-oxo-1,15-pentadecanlactam (4) is described. Michael addition of α-nitro cyclododecanone to acrylonitrile followed by selective reduction of nitrile group of 2 gave the ring enlargement product 3, which was easily converted to 4 through Nef reaction. The total yield was 28%. |
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| Keywords: | 12-oxo-1 15-pentadecanlactam Michael addition ring enlargement Nef reaction |
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