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排序方式: 共有86条查询结果,搜索用时 15 毫秒
1.
采用水提醇沉法将升巨散制成冲剂,对实验性血小板减少症的治疗,表明升巨散具有升高外周血小板数量之功效,差异显著(P<0.15).相继在出血时问、凝血时间和24h 血块收缩实验中,也间接证实本品有升高外周血小板数量之作用。又在骨髓象检查中,发现升巨散能提高骨髓之巨核细胞及血小板数量,差异显著。本品 LD_(50)及95%可信限为70.88±2.62g/kg。 相似文献
2.
The aim of the present work was to improve the discriminatory potential, and hence the probative value, of Y-STR-based testing by extending the set of Y chromosome STR loci available for forensic casework. In accordance with the requirements of a Y chromosome multiplex analytical system developed specifically for forensic casework use, we have sought to maximize the number of loci able to be co-amplified, ensure appropriate assay sensitivity (1–2 ng of input genomic DNA), balance inter-locus signals and minimize confounding female DNA artifacts. Two Y chromosome STR systems, multiplex I (MPI) and multiplex II (MPII), have been developed which permit the robust co-amplification of 18 Y-STRs. The loci include DYS19, DYS385(a) and (b), DYS388, DYS389I and II, DYS390, DYS391, DYS392, DYS393, DYS425, DYS434, DYS437, DYS438, DYS439, Y-GATA-C4, Y-GATA-A7.1 (DYS460) and Y-GATA-H4. The two multiplex systems are robust over a wide range of primer, magnesium, and DNA polymerase concentrations and perform well under a variety of cycling conditions. Complete male haplotypes can be obtained with as little as 100–250 pg of template DNA. Although a limited number of female DNA artifacts are observed in mixed stains in which the male DNA comprises 1/100 of the total, the male profile is easily discernible. Slightly modified versions of MPI and MPII demonstrate a significant reduction in female artifacts. Thus, it may not be necessary to employ a differential extraction strategy to obtain a male haplotype (or haplotypes in the case of multiple male donors) in cases of sexual assault. The potential utility of MPI and MPII for forensic casework is exemplified by their ability to dissect out the male haplotype in post-coital vaginal swabs and to determine the number of male donors in mixed semen stains.This study has emphasized the need for novel Y-STR multiplexes developed for forensic use to undergo a series of validation exercises that go beyond simply optimizing the PCR reaction conditions. Specifically, stringent performance checks on their efficacy need to be carried out using casework-type specimens in order to determine potential confounding effects from female DNA. 相似文献
3.
Summary The theory of the evaporation of the liquid stationary phase is elaborated and experimentally verified. On the basis of this theory the role played by the losses in the amount of liquid phase present is quantitatively determined. General techniques are examined which minimize the losses; these techniques are based on saturating the incoming carrier gas with liquid phase vapours and raising the pressure of the carrier gas in the column, e.g. by connecting a capillary to the column outlet in order to offer resistance to the gas flow. The application of these techniques ensures stable performance of the gas chromatographic columns using a volatile liquid phase. 相似文献
4.
对19头健康牦母牛在发情期中阴道粘液的变化情况进行了研究,结果表明,在友情盛期,牦母牛阴道粘液pH值为7;12±0.31,阴道分泌物抹片镜检可见大量无核上皮细胞,少量有核上皮细胞,很少见白细胞,并有52.6%牛只出现不同形状的粘液结晶;在发情末期,阴道粘液pH值为6.97±0.27,镜检可见上皮细胞减少,白细胞增多,粘液结晶出现率明显减少仅占31.2%;受试19头牦母牛中,受孕数13头,受胎率为68.4%,其中,10头出现粘液结晶的发情牦母牛全部受孕(100%),9头未发现粘液结晶的牛只仅受孕3头(33.3%),二者差异极显著(P<0.01),由此看出,牦母牛在友情期中阴道粘液结晶的出现率与会胎率成正相关。该研究结果为准确判定牦母牛发情期,指导过时输精及提高杂交受胎率,提供了简便易行的方法和基础参考数据。 相似文献
5.
6.
孙志琼 《广东微量元素科学》2017,24(5)
目的探讨细菌性阴道病和甲硝唑治疗对妊娠结局的影响。方法选取吉水县醪桥镇人口与计划生育服务所2014年7月至2015年7月收治的120例中晚期妊娠合并BV者,根据自愿原则分为治疗组和未治疗组(C组)。治疗组中口服用药为A组,阴道用药为B组。结果治疗组中两种不同用药方式都对妊娠合并BV患者有着显著的治疗效果,两组比较无统计学意义(P0.05);治疗组妊娠结局总不良率仅为10%,未治疗组中总不良率高达73.3%,对比差距显著,具备统计学意义(P0.05)。结论对妊娠期合并细菌性阴道病妇女使用甲硝唑治疗,对提升妊娠期妇女生活品质和降低不良妊娠风险有着关键的作用,同时具有十分重要的参考意义。 相似文献
7.
复合镍铁渣混凝土与普通混凝土在强度等同条件下,由于泌水效应,前者与水平钢筋的粘结强度显著弱于后者。针对此特性,基于已有试验,分析了掺复合镍铁渣混凝土梁柱中节点的变形特性。节点的变形主要归结为附属梁体的弯曲变形和梁纵筋滑移引起的梁柱界面附加转角变形,本文重点分析后者。从试验现象观察来看,梁体的受弯变形并不明显,而梁柱界面附加转角变形明显。采用数值方法分析了不同复合镍铁渣掺量下的梁柱界面附加转角变形对总体变形的影响。研究表明,随着复合镍铁渣掺量的增加,梁柱界面附加转角增加,占整体变形相当大的比例。提出了梁端等效塑性铰模型,确定了塑性铰长度与梁长、复合镍铁渣掺量、梁纵筋直径之间的关系,可以快速评估复合镍铁渣梁柱中节点的极限变形能力。 相似文献
8.
Scarlett Puebla-Barragan Emiley Watson Charlotte van der Veer John A. Chmiel Charles Carr Jeremy P. Burton Mark Sumarah Remco Kort Gregor Reid 《Molecules (Basel, Switzerland)》2021,26(15)
Lactobacillus crispatus is the dominant species in the vagina of many women. With the potential for strains of this species to be used as a probiotic to help prevent and treat dysbiosis, we investigated isolates from vaginal swabs with Lactobacillus-dominated and a dysbiotic microbiota. A comparative genome analysis led to the identification of metabolic pathways for synthesis and degradation of three major biogenic amines in most strains. However, targeted metabolomic analysis of the production and degradation of biogenic amines showed that certain strains have either the ability to produce or to degrade these compounds. Notably, six strains produced cadaverine, one produced putrescine, and two produced tyramine. These biogenic amines are known to raise vaginal pH, cause malodour, and make the environment more favourable to vaginal pathogens. In vitro experiments confirmed that strains isolated from women with a dysbiotic vaginal microbiota have higher antimicrobial effects against the common urogenital pathogens Escherichia coli and Enterococcus faecium. The results indicate that not all L. crispatus vaginal strains appear suitable for probiotic application and the basis for selection should not be only the overall composition of the vaginal microbiota of the host from which they came, but specific biochemical and genetic traits. 相似文献
9.
为优化发动机泄气制动性能,用UG软件建立了三维模型,应用动态网格技术对模型进行了网格划分并对气门和活塞的运动规律进行设置和定义.用Fluent软件对泄气制动工作过程进行三维瞬态数值模拟,分析了泄气制动过程活塞压力变化情况,并根据活塞瞬时受力得到各状态下发动机平均制动功率,得出排气背压、排气门开度、发动机转速对制动性能的影响.通过优化工作参数,提高了泄气制动性能,最后进行实验验证,结果表明最大误差为5.2%,最小误差仅为4.1%,表明模拟结果有较高精度和准确性. 相似文献
10.
L. Benkő J. Danis R. Hubmann G. Kasza Éva Gömöri Erzsébet Rőth D. Lőrinczy 《Journal of Thermal Analysis and Calorimetry》2009,95(3):763-768
Massive bleeding from esophagus varices presents a life threatening complication of portal hypertension. No effective method
of treatment is available until now, that would guarantee high grade of patient wellness during the conditioning and investigation
phase until the definitive treatment could be introduced. The aim of this study was to evaluate the tissue response to esophagus
stents - designed for manage acute variceal bleeding - in animal experiment.
Self-expandable nitinol stents were introduced into the esophagus of six porcines. Another twelve porcines were undergone
the same procedure, using the new biodegradable stents made of PDO (polydioxanon). Histological investigations of the stented
esophagus segments were observed after 2 and 4 weeks at the first 12 animals. To monitor the time of stent degradation, histology
were performed 7 and 12 weeks after the implantation in the biodegradable group (3–3 animals). Differential scanning calorimetric
examination was performed in all esophagus samples.
Focal erosion of the esophagus segments was more explicit in the nitinol group at the histology. On the 7th week all of the biodegradable stent were in the stomach and on the 12th week these were completely solved. DSC examination showed significant alterations in the structure of the esophagus in both
stented group compared to the healthy control.
This experiment showed that the new self-expandable stents are safety and suitable procedure without deterioration of the
esophageal wall. According to our DSC results the thermal denaturation of intact esophagus, its mucosa and muscle fragments
revealed significant differences compared to healthy sample in favour the new biodegradable stent. Safety and efficiency in
the experimental model had encouraged us to apply this method successfully patients with bleeding esophagus varices. The long
term goal is to show that stent placement could be an effective way of decreasing or stabilising the acute bleeding from ruptured
esophagus varices in cirrhotic patients. 相似文献