地理国情普查地表覆盖内业解译的质量问题研究

地表覆盖内业解译是地理国情普查的一道重要工序。地理国情地表覆盖内业解译现存图斑平面位置精度不足、分类错误多种多样等普遍问题,问题突出典型。文中针对这些问题图文并茂、清晰明了的进行了说明,并从多方面分析问题产生的原因,提出加强对技术指标和采集原则的学习和理解,加强内业与外业的结合,充分发挥解译样本的作用等建议,以有效提高内业解译的质量。     

Computational Design of Novel Allosteric Inhibitors for Plasmodium falciparum DegP

The serine protease, DegP exhibits proteolytic and chaperone activities, essential for cellular protein quality control and normal cell development in eukaryotes. The P. falciparum DegP is essential for the parasite survival and required to combat the oscillating thermal stress conditions during the infection, protein quality checks and protein homeostasis in the extra-cytoplasmic compartments, thereby establishing it as a potential target for drug development against malaria. Previous studies have shown that diisopropyl fluorophosphate (DFP) and the peptide SPMFKGV inhibit E. coli DegP protease activity. To identify novel potential inhibitors specific to PfDegP allosteric and the catalytic binding sites, we performed a high throughput in silico screening using Malaria Box, Pathogen Box, Maybridge library, ChEMBL library and the library of FDA approved compounds. The screening helped identify five best binders that showed high affinity to PfDegP allosteric (T0873, T2823, T2801, {"type":"entrez-protein","attrs":{"text":"RJC02337","term_id":"1480409465","term_text":"RJC02337"}}RJC02337, CD00811) and the catalytic binding site (T0078L, T1524, T2328, BTB11534 and 552691). Further, molecular dynamics simulation analysis revealed {"type":"entrez-protein","attrs":{"text":"RJC02337","term_id":"1480409465","term_text":"RJC02337"}}RJC02337, BTB11534 as the best hits forming a stable complex. WaterMap and electrostatic complementarity were used to evaluate the novel bio-isosteric chemotypes of {"type":"entrez-protein","attrs":{"text":"RJC02337","term_id":"1480409465","term_text":"RJC02337"}}RJC02337, that led to the identification of 231 chemotypes that exhibited better binding affinity. Further analysis of the top 5 chemotypes, based on better binding affinity, revealed that the addition of electron donors like nitrogen and sulphur to the side chains of butanoate group are more favoured than the backbone of butanoate group. In a nutshell, the present study helps identify novel, potent and Plasmodium specific inhibitors, using high throughput in silico screening and bio-isosteric replacement, which may be experimentally validated.     

唐代试律诗诗题用典与唐代祥瑞尚奇文化

唐代试律诗诗题对有关祥瑞及灵异之类典故的大量选用,不但体现了唐代统治者借祥瑞文化维护自身统治的治国策略,也表明了尚奇之风在唐代的盛行。     

微信公众平台在大学生安全教育中的应用

阐述微信公众平台的优势,分析利用微信公众平台开展大学生安全教育的可行性,通过突出信息推送功能、以案讲案、引导大学生参与平台建设等措施发挥微信公众平台载体作用,提出转变传统的安全教育观念、开发信息反馈功能、需要优秀编辑人员等完善微信公众平台运营的建议。     

基于课外学习的高职学生英语应用能力实证研究

以建构主义教学观为视角，研究课外学习对提高学生英语语言应用能力的有效性。实验结果表明，课外学习是构建英语语言学习环境的有效手段，对高职英语课堂教学有很大的促进作用，对提高学生的英语语言应用能力有明显作用。     

2018年天文学热点回眸

 天文学是一门以观测为基础的学科，其发展主要依靠观测和数据的支持。基于SAO/NASA Astrophysics Data System天文物理学数据系统中高被引文章并结合热点新闻报道，回顾了2018年天文学热点的进展和发现，以观测和基础研究、仪器研制及工具开发两大方面论述了2018年天文学研究热点。     

制度创新与提高政治参与水平--以浙江部分地区的民主实践为例

社会现代化的发展同时会带来提高政治参与水平的问题.现有的制度如果不能解决这一问题,就可能导致种种危机.因此一方面,执政党应通过制度创新来发展党内民主;另一方面,政府也应当开辟公民参与的新渠道,积极推动社会民主.此外,民间力量的崛起也为扩大政治参与注入了体制外的动力.     

对高职数控专业毕业综合实训的探讨

本文探讨了数控技术专业毕业综合实训的改革思路，提出按职业资格标准强化技能培训，使学生在毕业前获得数控机床操作职业资格证书，切实提高学生的职业素质与就业竞争能力。     

关于化学实验教学改革的研究

当前化学实验内容陈旧,联系实际较少,为适应素质教育的要求,应对实验教学进行改革,逐步形成科学的、先进的化学实验教学思路,以充分、全面的发挥化学实验教学的探究功能和育人功能。