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排序方式: 共有2968条查询结果,搜索用时 31 毫秒
1.
文化与语言有着密切的联系,一定的文化背景知识有助于促进语言应用能力的提高。大学英语教学的同时也应该是对文化的传授,英语教学不仅是语言知识的教授,更应该是文化知识的传播。从多模态视角出发,探究中国传统文化导入大学英语教学的必要性及途径,有助于提高当代大学生的英语识读能力及文化传播的能力。 相似文献
2.
Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry
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Dongyu Gu Yi Yang Qibin Chen Madina Habasi Jiangyu Zhao Haji Akber Aisa 《Biomedical chromatography : BMC》2015,29(4):595-603
Rupestonic acid, a potential anti‐influenza agent, is an important and characteristic compound in Artemisia rupestris L., a well‐known traditional Uighur medicine for the treatment of colds. In the present study, high‐performance liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry was used to detect and identify the metabolites in rat urine after oral administration of rupestonic acid. A total of 10 metabolites were identified or partially characterized. The structure elucidations of the metabolites were performed by comparing the changes in accurate molecular masses and fragment ions with those of the parent compound. The results showed that the main metabolites of rupestonic acid in rat urine were formed by oxidation, hydrogenation and glucuronidation. A metabolism pathway was proposed for the first time based on the characterized structures. This metabolism study can provide essential information for drug discovery, design and clinical application of rupestonic acid. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
3.
Md. Zia Uddin Arkajyoti Paul Ahmed Rakib Saad Ahmed Sami Shafi Mahmud Md. Sohel Rana Shahadat Hossain Abu Montakim Tareq Mycal Dutta Talha Bin Emran Jesus Simal-Gandara 《Molecules (Basel, Switzerland)》2021,26(4)
The current study attempted, for the first time, to qualitatively and quantitatively determine the phytochemical components of Elatostema papillosum methanol extract and their biological activities. The present study represents an effort to correlate our previously reported biological activities with a computational study, including molecular docking, and ADME/T (absorption, distribution, metabolism, and excretion/toxicity) analyses, to identify the phytochemicals that are potentially responsible for the antioxidant, antidepressant, anxiolytic, analgesic, and anti-inflammatory activities of this plant. In the gas chromatography-mass spectroscopy analysis, a total of 24 compounds were identified, seven of which were documented as being bioactive based on their binding affinities. These seven were subjected to molecular docking studies that were correlated with the pharmacological outcomes. Additionally, the ADME/T properties of these compounds were evaluated to determine their drug-like properties and toxicity levels. The seven selected, isolated compounds displayed favorable binding affinities to potassium channels, human serotonin receptor, cyclooxygenase-1 (COX-1), COX-2, nuclear factor (NF)-κB, and human peroxiredoxin 5 receptor proteins. Phytol acetate, and terpene compounds identified in E. papillosum displayed strong predictive binding affinities towards the human serotonin receptor. Furthermore, 3-trifluoroacetoxypentadecane showed a significant binding affinity for the KcsA potassium channel. Eicosanal showed the highest predicted binding affinity towards the human peroxiredoxin 5 receptor. All of these findings support the observed in vivo antidepressant and anxiolytic effects and the in vitro antioxidant effects observed for this extract. The identified compounds from E. papillosum showed the lowest binding affinities towards COX-1, COX-2, and NF-κB receptors, which indicated the inconsequential impacts of this extract against the activities of these three proteins. Overall, E. papillosum appears to be bioactive and could represent a potential source for the development of alternative medicines; however, further analytical experiments remain necessary. 相似文献
4.
高师武术普修课分块教学的实验研究 总被引:1,自引:0,他引:1
黄秀玉 《曲靖师范学院学报》2002,21(6):102-104
采用实验对比的方法 ,探讨武术普修课分块教学的可行性效果 .结果表明 ,武术普修课采用分块教学是可行的 ,且使学生的学习目的性更加明确 ,提高了教学效果 相似文献
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6.
毛细管气相色谱法测定中药中有机氯农药残留量 总被引:4,自引:0,他引:4
建立了江西省两种中药中有机氯农药残留量的气相色谱分析方法。样品以丙酮提取,在NaCl存在下,以正已烷进行液—液分配,提取液用H2SO4净化,采用DB—1701毛细管柱,GC—ECD检测有机氯农药残留量。最低检测限为1.0×10-3-5.0×10-3mg/kg,添加回收率为85.7%-115.2%,应用于实际样品中有机氯农药残留量的检测,获得了较为满意结果。 相似文献
7.
中药材中孳生粉螨的初步调查 总被引:1,自引:0,他引:1
本文采用清水漂浮法和塔氏电热集螨器分离法,共分离中药材样本124种,1240份,从中分离出粉螨45种,隶属7科23属.得出结论:中药材粉螨的污染严重,应加强对中药螨类的防治,以保护中药材及预防人体螨病. 相似文献
8.
李云喜 《科技情报开发与经济》2006,16(14):128-129
介绍了作业成本法的特点,从5个方面探讨了作业成本法与传统成本法的差别,指出作业成本法具有一定的先进性。 相似文献
9.
钟蔚 《武汉科技学院学报》2002,15(6):64-65
现代设计中传统文化作为旧的元素进行新的组合,从而强调个性化,形成民族化的设计只有立足民族化,面向国际化,才会使现代设计既有民族风格又充满时代气息。 相似文献
10.
孙雁军 《大连民族学院学报》2002,4(2):27-33
正确处理传统教科书与马克思主义哲学的关系是马克思主义哲学现代发展的关键环节.传统教科书不能完整准确地反映马克思的哲学思想,切断了实践与哲学基本问题的联系,曲解了马克思主义哲学,背离了马克思的哲学研究方向,扼杀了马克思主义哲学的实践作用.马克思主义哲学的现代发展必须首先破除对传统教科书和教科书式马克思主义哲学的固执和迷信。 相似文献