一种高性能英文词性标注器的设计与实现

针对统计和规则方法各自的优点和局限,提出运用Viterbi和FTBL(fast transformation-based learning)算法相级联的算法,实现一种英文自动词性标注器.该级联方法以FTBL算法为整体算法,在它的规则学习和最终标注两个阶段,均以Viterbi算法作为其初始化过程.实验结果表明此算法优于其中任何一种单独的算法,达到了98%的高准确率,验证了自然语言处理中统计与规则并举的主流设计思想.     

Automatic 3D tracking of cardiac material markers using slice-following and harmonic-phase MRI

A method to track a grid of cardiac material points in three dimensions using slice-following (SF) tagged magnetic resonance imaging (MRI) and harmonic-phase MRI is presented. A three-dimensional grid of material points on the lines of intersections of short-axis (SA) and long-axis (LA) planes is automatically tracked by combining two-dimensional pathlines that are computed on both SA and LA image planes. This process yields the true three-dimensional motion of points originating on the image plane intersections. Experimental data from normal volunteers, each obtained in four short breath-holds using the SF harmonic phase MRI pulse sequence, is presented. A validation of two-dimensional in-plane tracks using this pulse sequence on a moving phantom is also presented.     

基于最大熵模型的词位标注汉语分词

近年来基于字的词位标注汉语分词方法极大地提高了分词的性能,该方法将汉语分词转化为字的词位标注问题,借助于优秀的序列标注模型,词位标注汉语分词逐渐成为汉语分词的主要技术路线.该方法中特征模板集设定和词位标注集的选择至关重要,采用不同的词位标注集,使用最大熵模型进一步研究了词位标注汉语分词技术.在国际汉语分词评测Bakeoff2005的语料上进行了封闭测试,并对比了不同词位标注集对分词性能的影响.实验表明所采用的六词位标注集配合相应的特征模板集TMPT-6较其他词位标注集分词性能要好.     

核酸工具酶辅助的金属稳定同位素标记方法在生物分析中的应用

本文主要概述了近年来核酸工具酶辅助的基于金属稳定同位素标记的电感耦合等离子体质谱(ICP-MS)检测方法在生物分析中的发展和应用,简要介绍了该方法在蛋白质、核酸及一些生物小分子检测中的应用。最后对核酸工具酶辅助的基于金属稳定同位素标记的电感耦合等离子体质谱(ICP-MS)检测方法的发展前景做了展望。     

High Resolution Crossed Beams Scattering Study of the F＋HD→DF＋H Reaction

Crossed beams scattering study was carried out on the F＋HD→DF＋H reaction using high- resolution H-atom Rydberg tagging time-of-flight technique. Vibrational state-resolved differential cross sections were measured, with partial rotational state resolution, at eight collision energies in the range of 2.51-5.60 kJ/mol. Experimental results indicated that the product angular distributions are predominantly backward scattered. As the collision energy increases, the backward scattered peak becomes broader gradually. Dependence of product vibration branching ratios on the collision energy was also determined. The experimental results show that the DF products are highly inverted in the vibrational state distribution and the DF （v＇=3） product is the most populated state. Furthermore, the DF （v＇=l） product has also been observed at collision energy above 3.97 kJ/mol.     

Community-Based User Domain Model Collaborative Recommendation Algorithm

Collaborative Filtering (CF) is a commonly used technique in recommendation systems. It can promote items of interest to a target user from a large selection of available items. It is divided into two broad classes: memory-based algorithms and model-based algorithms. The latter requires some time to build a model but recommends online items quickly, while the former is time-consuming but does not require pre-building time. Considering the shortcomings of the two types of algorithms, we propose a novel Community-based User domain Collaborative Recommendation Algorithm (CUCRA). The idea comes from the fact that recommendations are usually made by users with similar preferences. The first step is to build a user-user social network based on users’ preference data. The second step is to find communities with similar user preferences using a community detective algorithm. Finally, items are recommended to users by applying collaborative filtering on communities. Because we recommend items to users in communities instead of to an entire social network, the method has perfect online performance. Applying this method to a collaborative tagging system, experimental results show that the recommendation accuracy of CUCRA is relatively good, and the online time-complexity reduces to O.n/.     

现代维吾尔语的词性标注校对技术研究

近些年来语料库语言学的发展较为迅速,语料库的建设成为一项重要的工作.在对语料加工的过程中,保证词性标注的一致性也成为建设高质量语料库的重要问题.目前国内外对汉语语料库词性标注结果的校对,还停留在人工校对上,对词性标注结果不一致现象尚未进行系统的研究.对于词性标注方法不是很成熟的维吾尔语语料库来说,词性校对方面的研究工作更少.首先概要介绍了一种维吾尔语的标注方法,并受一些文献的启发,根据维吾尔语的特点对其进行词性标注自动校对的研究,并分析其适用于维吾尔语词性校对的可行性,进而提高维吾尔语词性标注的正确率.     

Derivatization of peptides and small proteins for improved identification and detection in capillary zone electrophoresis (CZE)

Peptides and small proteins, of limited molecular weight (MW) can be derivatized with a 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (6-AQC) reagent, leading to a single capillary zone electrophoresis (CZE) peak, suggestive of a completely tagged product. The number of tags per molecule was demonstrated by matrix assisted, laser desorption, time-of-flight mass spectrometry (MALDI-TOFMS) studies. In CZE, these species have greatly improved plate count and peak shape, improved (lowered) detectabilities, and in general, improved identification properties in the CZE mode in high performance capillary electrophoresis (HPCE). The formation of what appears to be a single, homogeneously tagged product is a function of how the derivatizations are performed. Once these conditions are optimized, virtually all peptides and small proteins tested (limited MW) can form single, fully tagged products, with the desirable CZE properties. These derivatization approaches thus lead to products that perform and are detected much better in CZE than their precursors (native, untagged peptides). The determined plate counts for these tagged peptides were as high as 6 million plates/m, which was very reproducible, and 59–12,000 times higher than the untagged (native) molecules. The peak symmetry was also improved greatly. The limit of detection (LOD) of some tested 6-AQC tagged peptides were nine to 209 times improved (lower) with ultraviolet (UV) absorption detection, again as compared with that for the native species. The LOD could be further lowered via laser induced fluorescence (LIF) detection in CZE, especially when acetonitrile (ACN) containing buffers were used.     

Evaluation of isotope-coded protein labeling (ICPL) in the quantitative analysis of complex proteomes

An evaluation of the ICPL (isotope-coded protein labeling) non-isobaric labeling technique was performed using two different biological models. Two samples containing phage T4 capsids were mixed in a 1:1 ratio after being labeled with the light or heavy versions of the ICPL reagent. The analysis of this proteome demonstrated the feasibility of this approach for differential quantitative proteomics and was employed to optimize the experimental parameters of the ICPL workflow. ICPL-mediated analysis of two more complex proteomes, those of a Salmonella enterica serovar Typhimurium virulent strain and an isogenic attenuated mutant, and its comparison with the results obtained in a 2D-PAGE “classical” approach confirmed that ICPL is a valuable alternative to other labeling techniques currently in use. In addition, our results suggest that labeling at the peptide level instead of following the standard ICPL workflow should increase both the number of proteins quantified and the reliability of the quantification.     

未来十年纳米光子学若干重点发展领域

纳米光子学已经对人们的日常生活产生了重要影响,并且纳米光子学器件产品有强大的市场需求,因此其研究结果可以很快转化为商品。文章介绍了在未来5到10年内对光子工业有重大影响并且有望进入商品市场的11个纳米光子学领域,其中包括:纳米尺度量子光子学、全光路由、用于增强磁存储的表面等离子体光子学、用于诊断治疗和药物输送纳米光子学、纳米成像、分子尺度上的化学与生物传感器、纳米标签、纳米尺度上操控光场的分布(光伏器件和LED/OLED)、原型试制的新技术、量身定制光学特性的纳米光子材料以及太赫兹技术等,希望文章能对中国的纳米光子学研究及其工业化应用有一定帮助。