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排序方式: 共有116条查询结果,搜索用时 15 毫秒
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Yingying Ma Guangyan Zhang Lingjuan Li Huan Yu Jia Liu Chaoqun Wang Yanfeng Chu Renxi Zhuo Xulin Jiang 《Journal of polymer science. Part A, Polymer chemistry》2016,54(7):879-888
The pH‐sensitive tertiary amino groups were introduced to synthesize temperature and pH dual‐sensitive degradable polyaspartamide derivatives (phe/DEAE‐g‐PHPA) containing pendant aromatic structures and ionizable tertiary amino groups. The thermo/pH‐responsive behavior of phe/DEAE‐g‐PHPA polymer can be tuned by adjusting the graft copolymer composition. Due to the pH sensitivity of the phe/DEAE‐g‐PHPA‐g‐mPEG polymer with hydrophilic long PEG chain, the micelles and the anticancer drug‐loaded micelles were prepared by a quick pH‐changing method without using toxic organic solvent. The obtained polymeric micelles, paclitaxel‐loaded micelles and doxorubicin‐loaded micelles were stable under physiological conditions. Both the drug‐loaded micelles showed much faster release at pH 5 than at pH 7.4. The doxorubicin‐loaded micelles showed obvious and better anticancer activity against both HepG2 and HeLa cells than free doxorubicin. Thus these nontoxic, dual thermo‐ and pH‐sensitive phe/DEAE‐g‐PHPA‐g‐mPEG micelles may be a promising anticancer drug delivery system. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54, 879–888 相似文献
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Sayyeda M. Hasan Landon D. Nash Duncan J. Maitland 《Journal of polymer science. Part A, Polymer chemistry》2016,54(14):1300-1318
Porous shape memory polymers (SMPs) exhibit geometric and volumetric shape change when actuated by an external stimulus and can be fabricated as foams, scaffolds, meshes, and other polymeric substrates that possess porous three-dimensional macrostructures. These materials have applications in multiple industries such as textiles, biomedical devices, tissue engineering, and aerospace. This review article examines recent developments in porous SMPs, with a focus on fabrication methods, methods of characterization, modes of actuation, and applications. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016 , 54, 1300–1318 相似文献
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Dr. Shan Sun Qiao Chen Zhongdi Tang Chuang Liu Prof. Zhongjun Li Prof. Aiguo Wu Prof. Hengwei Lin 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(47):21227-21234
A method is developed to fabricate tumor microenvironment (TME) stimuli-responsive nanoplatform for fluorescence (FL) imaging and synergistic cancer therapy via assembling photosensitizer (chlorine e6, Ce6) modified carbon dots (CDs-Ce6) and Cu2+. The as-obtained nanoassemblies (named Cu/CC nanoparticles, NPs) exhibit quenched FL and photosensitization due to the aggregation of CDs-Ce6. Their FL imaging and photodynamic therapy (PDT) functions are recovered efficiently once they entering tumor sites by the stimulation of TME. Introducing of Cu2+ not only provides extra chemodynamic therapy (CDT) function through reaction with hydrogen peroxide (H2O2), but also depletes GSH in tumors by a redox reaction, thus amplifying the intracellular oxidative stress and enhancing the efficacy of reactive oxygen species (ROS) based therapy. Cu/CC NPs can act as a FL imaging guided trimodal synergistic cancer treatment agent by photothermal therapy (PTT), PDT, and thermally amplified CDT. 相似文献
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将组氨酸以共价键连接到酰氯化的聚丙烯酸分子网络上 ,设计合成作为智能高分子催化剂的聚丙烯酰胺支载咪唑基化合物 .将此类电响应高分子催化乙酸 p -硝基苯酯的水解反应 ,用荧光分光光度计跟踪监测反应的进程 ,分析在一定频率的电场刺激响应下不同交联密度对催化活性的影响 . 相似文献
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作者采用阴茎电极器法对太行山猕猴进行了电刺激采精试验.太行山猕猴采精刺激参数平均值为:电压22~28V;频率30Hz;波宽10ms.平均刺激8.4s开始排精,平均采精量3.95g/次.比较发现,阴茎电极器法采精量明显高于直肠探子法. 相似文献
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The self-consistent field theory has been employed to numerically study the response of bi-disperse flexible polyelectrolyte (PE) brushes grafted on an electrode to electric fields generated by opposite surface charges on the PE-grafted electrode and a second parallel electrode. The numerical study reveals that, under a positive external electric field, the shorter and negatively charged PE chains are more responsive than the longer PE chains in terms of the relative changes in their respective brush heights. Whereas under a negative external electric field, the opposite was observed. The total electric force on the grafted PE chains was calculated and it was found that, under a positive external electric field, the magnitude of the total electric force acting on one shorter PE chain is larger than that on one longer PE chain, or vice versa. The underlying mechanism was unraveled through analyzing the total electric field across the two oppositely charged electrodes. 相似文献
9.
Bo‐yu Zhang Wei‐Dong He Li‐ying Li Xiao‐li Sun Wen‐tao Li Ke‐ren Zhang 《Journal of polymer science. Part A, Polymer chemistry》2010,48(16):3604-3612
Reducibly degradable hydrogels of poly(N‐isopropylacrylamide) (PNIPAM) and poly(N,N‐dimethylaminoethyl methacrylate) (PDMAEMA) were synthesized by the combination of reversible addition‐fragmentation chain transfer (RAFT) polymerization and click chemistry. The alkyne‐pending copolymer of PNIPAM or PDMAEMA was obtained through RAFT copolymerization of propargyl acrylate with NIPAM or DMAEMA. Bis‐2‐azidyl‐isobutyrylamide of cystamine (AIBCy) was used as the crosslinking reagent to prepare reducibly degradable hydrogels by click chemistry. The hydrogels exhibited temperature or pH stimulus‐responsive behavior in water, with rapid response, high swelling ratio, and reproducible swelling/shrinkage cycles. The loading and release of ceftriaxone sodium proved the feasibility of the hydrogels as the stimulus‐responsive drug delivery system. Furthermore, the presence of disulfide linkage in AIBCy favored the degradation of hydrogels in the reductive environment. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 3604–3612, 2010 相似文献
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鲍骏 《海军工程大学学报(综合版)》2010,7(3):49-53
当前,水面舰艇部队日益频繁地执行护航、出访、演习等航程跨度大、持续时间长的长航任务,随之而来的是舰艇官兵沉重的心理压力。舰艇官兵的心理症状和心理异常与其在长航任务中所受到的工作压力刺激的频率、突发事件刺激的强度、个体对压力和刺激事件的认知、应对方式以及群体的情感态度等有密切关系。要采取语言倾诉、认知疏导、群体关怀、音乐调节、自我调适等手段,对长航任务中的舰艇官兵进行全程不间断的心理干预。 相似文献