Spray Freeze-drying – The Process of Choice for Low Water Soluble Drugs?

Most of the novel highly potent drugs, developed on the basis of modern molecular medicine, taking into account cell surface recognition techniques, show poor water solubility. A chemical modification of the drug substance enhancing the solubility often decreases the pharmacological activity. Thus, as an alternative an increase of the solubility can be obtained by the reduction of the size of the drug particles. Unfortunately, it is often difficult to obtain micro or nanosized drug particles by classical or more advanced crystallization using supercritical gases or by milling techniques. In addition, nanosized particles are often not physically stable and need to be stabilized in an appropriate matrix. Thus, it may be of interest to manufacture directly nanosized drug particles stabilized in an inert hydrophilic matrix, i.e. nanostructured and nanocomposite systems. Solid solutions and solid dispersions represent nanostructured and nanocomposite systems. In this context, the use of the vacuum-fluidized-bed technique for the spray-drying of a low water soluble drug cosolubilized with a hydrophilic excipient in a polar organic solvent is discussed. In order to avoid the use of organic solvents, a special spray-freeze-drying technique working at atmospheric pressure is presented. This process is very suitable for temperature and otherwise sensitive drugs such as pharmaproteins.     

关于洛仑兹变换

论述洛仑兹变换及其四维形式的由来，并分析了物理量的变换性质。     

新型立体垂直塔板的开发现状

新型立体垂直筛板是近年来应用较为广泛的一种筛板,其主要特点是气液并流接触,传质在塔板空间内进行.本文对近年来开发的几种新型立体垂直筛板进行了详细的介绍,对其流体力学性能进行了比较,并对其发展前景进行了预测     

三球式和转台式角动量守恒演示器的研制与应用

本文详细介绍了笔者研制的三球式和转台式两种新型角动量守恒演示器的结构、特点和使用方法。     

“Slow” active control of combustion instabilities by modification of liquid fuel spray properties

This paper describes an experimental investigation of the feasibility of using “slow” active control approaches, which “instantaneously” change liquid fuel spray properties, to suppress combustion instabilities. The objective of this control approach was to break up the feedback between the combustion process heat release and combustor pressure oscillations that drive the instability by changing the characteristics of the combustion process (e.g., the characteristic combustion time). To demonstrate the feasibility of such control, this study used a proprietary fuel injector (Nanomiser^TM), which can vary its fuel spray properties, to investigate the dependence of acoustics–combustion process coupling, i.e., the driving of combustion instabilities, upon the fuel spray properties. This study showed that by changing the spray characteristics it is possible to significantly damp combustion instabilities. Furthermore, using combustion zone chemiluminescence distributions, which were obtained by Abel’s deconvolution synchronized with measured acoustic data, it has been shown that the instabilities were mostly driven midway between the combustor centerline and wall, a short distance downstream from the flame holder, where the mean axial flow velocity is approximately zero in the vortex near the flame holder. The results of this study strongly suggest that a “slow” active control system that employs controllable fuel injectors could be effectively used to prevent the onset of detrimental combustion instabilities.     

Symmetries of Itô and Stratonovich Dynamical Systems and Their Conserved Quantities

A new definition for the symmetries of Itô and Stratonovich dynamicalsystem is given. Determining systems of symmetries for Itô andStratonovich systems have been obtained, and their relation has beendiscussed. It has been shown that some of the Lie point symmetries ofthe Fokker–Planck equation can be constructed using the symmetries ofItô dynamical systems. Conserved quantities can be found from thesymmetries of stochastic dynamical systems which do not arise from aHamiltonian. The results have been applied to an example.     

数形结合法的几个应用

把数学问题中的数量关系和形象直观的几何图形有机地结合起来,使问题化难为易,化繁为简,从而达到解决问题的目的。     

引射式射流风机结构参数的研究

根据地下通风工程以较小的能耗获得较大风量的需要，运用流体力学的基本理论和模型试验研究方法，系统研究了引射式射流风的通风原理和结构参数，为引射式射流风机的设计提供依据。     

统计因素分析法刍议

本文主要就统计因素分析法中不变因素的固定时期问题．提出了“先变因素和后变因素”的观点，从而对统计指数理论难以解释的问题．变得较为容易处理。     

仓库容量有限条件下的一类存贮管理模型

建立了一类仓库容量有限条件下存贮管理决策模型 ,给出最优存贮策略 .