SASEGASA: A New Generic Parallel Evolutionary Algorithm for Achieving Highest Quality Results

This paper presents a new generic Evolutionary Algorithm (EA) for retarding the unwanted effects of premature convergence. This is accomplished by a combination of interacting generic methods. These generalizations of a Genetic Algorithm (GA) are inspired by population genetics and take advantage of the interactions between genetic drift and migration. In this regard a new selection scheme is introduced, which is designed to directedly control genetic drift within the population by advantageous self-adaptive selection pressure steering. Additionally this new selection model enables a quite intuitive heuristics to detect premature convergence. Based upon this newly postulated basic principle the new selection mechanism is combined with the already proposed Segregative Genetic Algorithm (SEGA), an advanced Genetic Algorithm (GA) that introduces parallelism mainly to improve global solution quality. As a whole, a new generic evolutionary algorithm (SASEGASA) is introduced. The performance of the algorithm is evaluated on a set of characteristic benchmark problems. Computational results show that the new method is capable of producing highest quality solutions without any problem-specific additions.     

一种改善遗传算法早熟现象的方法

讨论了遗传算法(GA)中遗传算子对于改善群体整体品质实现群体进化的作用以及遗传算法中早熟现象的成因．通过动态调整遗传算法中的交叉概率和变异概率引入自适应算子，并与局部退化算子相结合来抑制早熟现象．最后给出了算例，说明该方法对于改善遗传算法中早熟现象以及提高算法效率有良好的作用．     

沥青路面早期损坏的现象与试验分析

首先对纷杂的早期损坏现象进行了归纳分类，又通过对若干条高等级路面的实地调查发现了4种新的损坏现象．试验分析表明，大空隙率增大了沥青混凝土的透水性、降低了耐久性和抗拉强度，对沥青与集料的粘附性提出了更高的要求，而常用的沥青混合料空隙率设计处于这一不利的空隙率区间．大空隙率与荷载和水的综合作用是诱发早期损坏的主要原因．     

Ameliorative Effect of Citrus Lemon Peel Extract and Resveratrol on Premature Ovarian Failure Rat Model: Role of iNOS/Caspase-3 Pathway

Premature ovarian failure (POF) is described as a loss of oocytes and the absence of folliculogenesis and is considered an adverse effect of chemotherapeutic drugs, which leads to infertility. Subsequently, the existing inquiry was achieved by exploring the potential suspicious influences of lemon peel extract (LPE), and resveratrol (RES) on cyclophosphamide (CPA) induced-POF. The results showed that CPA-induced POF significantly decreased serum estradiol (E2) and progesterone levels, along with a considerable rise in serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels. Moreover, CPA administration to rats significantly increased the serum level of Malondialdehyde (MDA) and significantly lowered the levels of reduced glutathione (GSH) and superoxide dismutase (SOD); in addition, it increased nuclear factor kappa B (NF-κB) levels, tumor necrosis factor-α (TNF-α), as well as cyclooxygenase 2 (COX-2) with the spread expression of inducible nitric oxide synthase (iNOS) mRNA levels and caspase-3 (Casp3) levels in ovarian tissues versus the control rats. However, treatment with LPE and RES suppressed the triggering of NF- κB pathways, evidenced by a considerable reduction in Casp3 & iNOS mRNA expression level and significant ameliorative effects in all evaluated parameters, as confirmed by the histological and immunohistochemical investigation when comparing the model group. In overall findings, both lemon peel extract and resveratrol can mitigate the adverse effects of CPA-induced POF. Most crucially, its combination therapy is a promising pharmacological agent for this disease.     

早期干预对早产儿发展的影响

目的:探讨早期干预对早产儿发展的影响.方法:儿童系统管理中38例接受早期干预的早产儿为干预组(Ⅰ组);43例未接受早期干预的早产儿为对照组(Ⅱ组).结果:Ⅰ、Ⅱ组体重、身高SDS值比较,出生时两组差异无统计学意义(P>0.05),出生后3、6、12、24个月各年龄段比较差异有统计学意义(P<0.01);3个月时MDI、PDI值Ⅰ、Ⅱ组差异无统计学意义(P>0.05),但6、12、24月个各年龄段,Ⅰ组MDI、PDI值明显优于Ⅱ组,经检验,差异有统计学意义(P<0.01).结论:早期干预可以促进早产儿生长发育,有利于早产儿智能发育.     

半刚性基层沥青路面结构特性分析

针对高速公路半刚性基层沥青路面的早期损坏,从路面结构层层间状态、路面抗裂、路面荷载特性、路面耐水性、路面养护特性等5方面分析了半刚性基层沥青路面结构特点,提出防止路面早期损坏的措施。     

丁酸钠对M期同步及非同步的HeLa细胞早G_1期阻断的可逆性

本文采用早熟染色体凝集(PCC)和~3H-TdR显微自显影技术,观察丁酸钠对同步及非同步的HeLa细胞早G_1期阻断的可逆性及其可逆的进程。实验发现丁酸钠对HeLa细胞早G_1期阻断完全是可逆的,且这种可逆是在洗去丁酸钠后立即产生,丁酸钠对HeLa细胞早G_1期阻断的时间点发生在细胞进入S期前的9.5h;发现早G_1期阻断后的恢复必须再经过中、晚G_1期然后才能进入S期.     

Crying and Behavioral Characteristics in Premature Infants

The aims of this study were to analyze 1) whether there was the relationship between the neonatal behavioral characteristics and amount of crying in premature infants at term age, and 2) what kind of difference between infants with high levels of crying and cry less on neonatal behavioral characteristics using the Neonatal Behavioral Assessment Scale (NBAS). The study participants consisted of 69 healthy low birth-weight infants who were admitted to the NICU at the Nagasaki University Hospital, Nagasaki, Japan. This study analyzed the relationship between NBAS scores measured neonatal behavioral performance and crying at term age. This study results indicate that there was significant statistical negative correlation between the amount of total daily crying and Habituation, Range of state, Regulation of state, and Autonomic stability cluster scores and some individual items scores (Response decrement to light, Response decrement to tactile of foot, Alert responsiveness, Examiner persistence, Motor maturity, Irritability, General irritability, Cuddliness, Consolability, Self-quieting activity, and State regulation). The high levels crying group also showed higher responsivity than less crying group in the items of Peak of excitement, Rapidity of build-up, Irritability and General irritability. In conclusion, neonatal behavioral characteristics such as poor inhibit discrete stimuli while asleep, hyper-responsivity and poor state regulation abilities were risk factors of high levels of crying.     

一种快速综合性的遗传算法

对几种改进的遗传算法进行了比较、分析、综合了这几种改进的遗传算法的优缺点后，提出了一种快速综合性的遗传算法，该算法具有收敛速度快，迭代次数少且不易陷入不成熟收敛等特点。仿真结果证实了该算法的有效性。     

模糊逻辑推理方法在室性早搏检测中的应用研究

尝试用模糊逻辑推理方法模仿人的知识表达和推理过程，进行室性早搏的实时自动检测．用ＭＩＴ心律失常数据库对算法所作的评价结果表明，该算法是异位心搏自动检测的一个有效方法．