Neutral lipids from seeds of <Emphasis Type="Italic">Cercis siliquastrum,Sapium sebiferum</Emphasis>, and <Emphasis Type="Italic">Koelreuteria paniculata</Emphasis>

The chemical composition of neutral lipids from seeds of Cercis siliquastrum, Sapium sebiferum, and Koelreuteria paniculata were studied. Characteristic features of their individual classes were established. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 318–319, July–August, 2007     

Rotenoid and isoflavone metabolites from an antioxidant seed extract of Dalbergia lanceolaria subsp. paniculata (roxb.) thoth

Abstract

A new rotenoid named 12-O-methylrotenolol along with five known rotenoid and isoflavone metabolites were isolated from the seeds of Dalbergia lanceolaria subsp. paniculata, collected from Egypt. The structures of these compounds were identified by physical and spectroscopic data measurements ([α]_D, UV, 1D- and 2D-NMR and MS). The methanol extract of the seeds exhibited strong antioxidant activity with IC₅₀ value 0.7?µg/µl against DPPH radical, in respect to quercetin as antioxidant reference (IC₅₀ 1.5?μM), while the tested compounds from this extract showed weak activities with IC₅₀ values ranged from 19.6 to 33.0?µM.     

Constituents of Flowers of Murraya Paniculata

Three new coumarins, yuehgesin-A (1), -B (2) and -C (3) and 22 compounds—murracarpin (4), mupanidin (5), isomeranzin (6), murralongin (7), scopoletin (10), 7-methoxy-8-(l′-ethoxy-2′-hydroxy-3′-methyl-3′-butenyl)coumarin (11), umbelliferone (12), paniculatin (13), braylin (14), auraptenol (15), meranzin hydrate (16), minumicrolin (17), scopolin (18), caffeine (19), 3,3′,4′,5,5′,6,7-heptamethoxyflavone (20), 4-hy-droxybenzaldebyde (21), p-hydroxybenzoic acid (22), cis- and trans-ferulic acid (23), cis- and transmethyl ferulate (24) and trans-ethylferulate (25)—were isolated and characterized from fresh flowers of Murraya paniculata collected in Taiwan. Their structures were elucidated by spectral methods. The chemotaxonomy of Murraya paniculata is, discussed.     

栾树不同单株种子品质差异性分析

对采自江西农业大学校园内10株栾树种子的播种品质和营养成分含量进行分析,结果表明：不同单株栾树种子发芽品质和营养物质的积累存在差异,在采种母树选择上,除种源外还要考虑单株的筛选;10个单株中,5号千粒重最重,达9.04 g,种子发芽性状及营养物质积累均处于较高水平,为10个单株中的优良单株;种子千粒重、含水量达到极显著...     

A new ent-labdane eiterpenoid lactone from Andrographis paniculata

A new ent-labdane diterpenoid lactone with a new natural product was isolated from Andrographis paniculata. Their structures were elucidated on the basis of spectral evidences including 2D NMR.     

白檀果肉红色素含量测定及基本理化性质的初步研究

本文优选了白檀果肉红色素的提取溶剂、测定该色素的含量,并对该色素的基本理化性质进行了初步研究,结果表明:1.5mol/LHCl-50%乙醇(V/V=15:85)是其最佳提取溶剂.色素含量为604.48mg/100g.该色素为水醇兼溶花色苷类色素,在酸性条件下稳定且色泽鲜艳.     

Separation of five compounds from leaves of Andrographis paniculata (Burm. f.) Nees by off‐line two‐dimensional high‐speed counter‐current chromatography combined with gradient and recycling elution

An off‐line two‐dimensional high‐speed counter‐current chromatography method combined with gradient and recycling elution mode was established to isolate terpenoids and flavones from the leaves of Andrographis paniculata (Burm. f.) Nees. By using the solvent systems composed of n‐hexane/ethyl acetate/methanol/water with different volume ratios, five compounds including roseooside, 5,4′‐dihydroxyflavonoid‐7‐O‐β‐d ‐pyranglucuronatebutylester, 7,8‐dimethoxy‐2′‐hydroxy‐5‐O‐β‐d ‐glucopyranosyloxyflavon, 14‐deoxyandrographiside, and andrographolide were successfully isolated. Purities of these isolated compounds were all over 95% as determined by high‐performance liquid chromatography. Their structures were identified by UV, mass spectrometry, and ¹H NMR spectroscopy. It has been demonstrated that the combination of off‐line two‐dimensional high‐speed counter‐current chromatography with different elution modes is an efficient technique to isolate compounds from complex natural product extracts.     

Rapid Simultaneous Determination of Andrographolides in Andrographis paniculata by Near-Infrared Spectroscopy

The potential of near-infrared spectroscopy (NIRS) for the quality control of traditional Chinese medicine has been evaluated. Seven quantitative parameters, andrographolide, deoxyandrographolide, dehydroandrographolide, neoandrographolide, moisture, ash content, and alcohol-soluble extract of Andrographis paniculata, were evaluated by NIRS. The reference values of andrographolides were determined by high-performance liquid chromatography, and the others were obtained using the standard methods of the 2015 Chinese Pharmacopoeia. The predicted values were determined by a quantitative model using NIRS based on partial least square regression. Different spectral preprocessing methods, spectral ranges, and optimum number of factors were selected to optimize the models. All models were estimated by the combination of various parameters, including the correlation coefficient of calibration for andrographolide, deoxyandrographolide, dehydroandrographolide, neoandrographolide, moisture, ash content, alcohol-soluble extract (values of 0.980, 0.984, 0.989, 0.983, 0.987, 0.988, 0.979, respectively), root mean square error of calibration (values of 0.156, 0.038, 0.050, 0.029, 0.604, 0.431, 0.135, respectively), root mean square error of prediction (values of 0.169, 0.041, 0.050, 0.033, 0.280, 0.493, 0.140, respectively), root mean square error of cross-validation (values of 0.626, 0.114, 0.158, 0.046, 1.145, 0.774, 0.508, respectively), and ratio of standard deviation to standard error of prediction (values of 4.583, 4.690, 4.796, 4.899, 4.899, 4.690, 5.099, respectively). The results show that the calibration models by NIRS are reliable and can be applied for the quantification for seven parameters from A. paniculata for quality control in traditional Chinese medicine production and processing.     

观赏植物矮化培养研究

通过试验筛选出适合万寿菊、满天星快速繁殖的培养基．矮壮素可使满天星和万寿菊丛苗数量减少,植株生长明显受抑制,使其节间缩短,叶片增厚,叶色浓绿．矮壮素还有使万寿菊根系发达粗壮,分支较少的作用．500mg／L的矮壮素比较适宜矮化培养,既达到了矮化的效果又不至于阻碍植株正常生长,且试管苗株形紧凑、美观．     

Pharmacokinetic Herb-Drug Interactions of Glipizide with Andrographis paniculata (Burm. f.) and Andrographolide in Normal and Diabetic Rats by Validated HPLC Method

Co-administered medicinal herbs can modify a drug’s pharmacokinetics (PK), effectiveness, and toxicity. Andrographis paniculata (Burm. f.) ethanolic extract (APE) and andrographolide (AND) (a potent CYP2C9 inducer/inhibitor) can alter the pharmacokinetic parameters of glipizide (GLZ). This study aimed to determine the potential pharmacokinetics of herb–drug interactions between GLZ and APE/AND in the plasma of normal and diabetic rats using the HPLC bioanalysis method. The glipizide bioanalytical method established with RP-HPLC/UV instrument was validated following the EMA guidelines. GLZ was administered alone and in combination with APE or AND to normal and diabetic rats. The GLZ pharmacokinetic parameters were estimated according to the correlation between concentration and sampling time using the PK solver program. A simple and rapid GLZ bioanalysis technique with a lower limit of quantitation of 25 ng/mL was developed and presented the following parameters: accuracy (error ≤ 15%), precision (CV ≤ 15%), selectivity, stability, and linearity (R² = 0.998) at concentrations ranging 25–1500 ng/mL. APE administration significantly improved the C_max and AUC_0–t/AUC_0–∞ GLZ values in normal and diabetic rats (p < 0.05). AND significantly reduced the bioavailability of GLZ in diabetic rats with small values of T 1/2, C_max, and AUC_0–t/AUC_0–∞ (p < 0.05). This combination can be considered in administering medications because it can influence the pharmacological effects of GLZ.