水合鸢尾异黄酮磺化物[K（H2O）]（C17H13O6SO3）的合成及晶体结构

目的 合成一种新的水溶性水合鸢尾异黄酮磺化衍生物[K(H2O)](C17H13O6SO3),并确定其分子结构.方法 在60 ℃条件下用浓H2SO4磺化30 min,得到尼泊尔鸢尾异黄酮磺化物,并用体积比为 1/1 的乙醇-水溶液培养单晶,采用X-射线四圆衍射、IR和元素分析等方法表征其结构.结果 和结论将尼泊尔鸢尾异黄酮在60 ℃用浓硫酸磺化,高选择性地在底物B环的3′位引入一个磺酸基,合成了水溶性尼泊尔鸢尾异黄酮衍生物,产率为82%.该合成方法简单,反应条件温和,选择性高,产物容易分离,且产率较高,是合成标题化合物一种理想的方法.X-射线晶体结构表明该化合物属于单斜晶系,空间群P21m,晶胞参数a=0.835(4) nm,b=0.728(3) nm,c=3.000(14) nm,β = 96.09(7)°,V=1.814(15) nm3,Dc=1.650 g·cm-3,Z=4.在化合物的晶体结构中, 相邻的钾离子之间被O6,O7和O8桥链形成聚八面钾离子链.此外,化合物中还存在多个氢键,这使化合物自组装成一个三维网格结构的超分子.     

Syntheses and crystal structures of [Na(H2O)](C17H13O6SO3)* 2H2O and [NKH2O)6]C17H13O6SO3)2*H2O

Two hydrates of sodium 5,7‐dihydroxy‐6,4′‐dimethoxyisoflavone‐3′‐sulfonate ([Na(H₂O)J(C₁₇H₁₃O₆SO₃)*2H₂O,] 1) and nickel 5,7‐dihydroxy‐6,4′‐dimethoxyisoflavone‐3′‐sulfonate ([Ni(H₂O)₆](C₁₇H₁₃O₆SO₃)₂*4H₂O, 2) were synthesized and characterized by IR, 'H NMR and X‐ray diffraction analyses. The hydrate 1 crystallizes in the mono‐clinic system, space group P2(1) with a=0.8201(9) nm, b=0.8030(8) nm, c= 1.5361(16) nm, β=102.052(12)°, V =0.9893(18) nm³, D,= 1.579 g/cm³, Z=2, μ=0.252 nm^?1, F(000)=488, R=0.0353, wR=0.0873. The hydrate 2 belongs to triclinic system, space group P‐1 with a=0.7411(3) nm, b=0.8333(3) nm, c=1.7448(7) nm, α= 86.361(6)°, β=86.389(5)°, γ= 88.999(3)°, V=1.0731(7) nm³, D,=1.587 g/cm³, Z=1, μ=0.649 m^?1, F(000)= 534. In the structure of 1, the sodium cation is coordinated by six oxygen atom and two adjacent ones are bridged by three oxygen atoms to form an octahedron chain. The C? H…?… hydrogen bonds exist between two isoflavone molecules in the structure of 2. Meanwhile, hydrogen bonds in two compounds, link themselves to assemble two three‐dimensional network structures, respectively.