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Qamar Uddin Ahmed Abdul Hasib Mohd Ali Sayeed Mukhtar Meshari A. Alsharif Humaira Parveen Awis Sukarni Mohmad Sabere Mohamed Sufian Mohd. Nawi Alfi Khatib Mohammad Jamshed Siddiqui Abdulrashid Umar Alhassan Muhammad Alhassan 《Molecules (Basel, Switzerland)》2020,25(23)
In recent years, there is emerging evidence that isoflavonoids, either dietary or obtained from traditional medicinal plants, could play an important role as a supplementary drug in the management of type 2 diabetes mellitus (T2DM) due to their reported pronounced biological effects in relation to multiple metabolic factors associated with diabetes. Hence, in this regard, we have comprehensively reviewed the potential biological effects of isoflavonoids, particularly biochanin A, genistein, daidzein, glycitein, and formononetin on metabolic disorders and long-term complications induced by T2DM in order to understand whether they can be future candidates as a safe antidiabetic agent. Based on in-depth in vitro and in vivo studies evaluations, isoflavonoids have been found to activate gene expression through the stimulation of peroxisome proliferator-activated receptors (PPARs) (α, γ), modulate carbohydrate metabolism, regulate hyperglycemia, induce dyslipidemia, lessen insulin resistance, and modify adipocyte differentiation and tissue metabolism. Moreover, these natural compounds have also been found to attenuate oxidative stress through the oxidative signaling process and inflammatory mechanism. Hence, isoflavonoids have been envisioned to be able to prevent and slow down the progression of long-term diabetes complications including cardiovascular disease, nephropathy, neuropathy, and retinopathy. Further thoroughgoing investigations in human clinical studies are strongly recommended to obtain the optimum and specific dose and regimen required for supplementation with isoflavonoids and derivatives in diabetic patients. 相似文献
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Effects of Genistein and Daidzein on the Proliferation, Invasion, Migration and Adhesion of Melanoma Cells 总被引:1,自引:0,他引:1
IntroductionGenistein and daidzein (Fig.1 ) ,two majorisoflavonoids in soybeans,were reported to playimportant roles in cancer prevention[1 ,2 ] .Previousstudies demonstrated that genistein and daidzeininhibited the growth of leukemia,breast,colonand prostate cancers[38] .Our earlier studies alsodemonstrated that daidzein enhanced the immunefunction in mice[9,1 0 ] . These functions madegenistein and daidzein promising candidates forcancer prevention. However,it is usually themetastatic disse… 相似文献
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In this research, total and free daidzein content in Genista species growing in Turkey were investigated using the LC-MS method. The highest amount of total and free daidzein in these
species was found in Genista sessilifolia and G. lydia var. antiochia as 0.0056 and 0.0009%, respectively. Total and free daidzein content of the aerial parts of other Genista species varied from 0.0003 to 0.0044%, and from 0.0001 to 0.0008%, respectively.
Published in Khimiya Prirodnykh Soedinenii, No. 5, pp. 417–418, September–October, 2006. 相似文献
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IntroductionMolecularpolymerwithonedimensionalormultidimen sionalstructureassemblingthroughhydrogenbondsisanim portantresearchcontentinthesupramolecularchemistryandcrystalenginnering .1,2 Withthedevelopmentofnewtypefunctionalmaterialssuchasmolecularmagnetic ,selectedcatalysis ,reversiblecatalysis ,reversiblehost guestmolecular(ion)exchangeetc.,3themoleculardesignandsynthesishavealreadyattractedconsiderableattentioninsupramolecu larsystem .Thesupramolecularcomplexesandorganiccom poundscontainin… 相似文献
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给脑老化模型小鼠灌喂不同剂量(5,10 mg·kg-1·d-1)的大豆黄酮.5 周后分别进行开场、一次性被动回避反应和空间学习记忆3种行为实验检测,结果显示大豆黄酮对衰老小鼠在新异环境下的自发活动状态、记忆保持能力、空间学习记忆能力等方面的行为表现有明显的改善作用,但不能根本改变.表明大豆黄酮可以部分延缓脑老化小鼠学习记忆能力下降. 相似文献
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日粮中添加大豆黄酮对大鼠生长及疲劳应激反应能力的影响 总被引:1,自引:0,他引:1
日粮中添加大豆黄酮,研究其对大鼠生长及抗疲劳应激能力的影响.结果显示,添加大豆黄酮组大鼠平均增重显著提高(P〈0.05),料重比显著降低(P〈0.05),表明大豆黄酮具有显著促生长作用.与正常对照组相比,疲劳应激对照组大鼠血清GSH-Px活性极显著下降(P〈0.01),MDA含量显著上升(P〈0.05),血糖含量极显著上升(P〈0.01),胰岛素水平有所升高而IL-2水平有所降低,差异均不显著(P〉0.05).与疲劳应激对照组相比,大豆黄酮疲劳应激组GSH-Px活性极显著上升(P〈0.01),血糖含量显著上升(P〈0.05),胰岛素水平显著下降(P〈0.05),MDA含量有所下降,IL-2水平有所上升,但差异均不显著(P〉0.05).结果提示,日粮中添加大豆黄酮一定程度上能增强机体抗疲劳能力. 相似文献
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合成新型大豆甙元衍生物Cd(II)配合物[Cd(L)(H2O)3]•2H2O (H2L=3'-磺酸钠-4'-羟基-7-羧甲基异黄酮), 采用单晶X射线衍射、元素分析和IR对其进行表征. 该配合物属单斜晶系, 空间群为P21/a, 晶胞参数a=1.3691(3) nm, b=0.72157(16) nm, c=2.0163(5) nm, α=90°, β=93.501(4)°, γ=90°, V=1.9882(8) nm3, Mr=592.79, Z=4, Dc=1.980 g•cm-3, F(000)=1192, μ=1.283 mm-1, R1=0.0387, wR2=0.1224. X射线单晶衍射分析结果表明, 该单晶中Cd(II)为六配位, 它除了与配体L中羧基和磺酸基上的氧原子配位外, 还与溶剂中的3个水分子发生配位, 形成了以Cd(II)为中心的八面体配位构型. 该晶体结构中存在着平行于b轴的双螺旋链, 左手螺旋Cd-L链和右手螺旋Cd-L链的交替排列构成了二维层状结构. 由于配位水和晶格水以及配体中CO2, SO3, O, CO, OH等的存在, 该晶体中存在着丰富而复杂的氢键, 二维层状结构之间依靠这些复杂的氢键作用形成三维超分子结构. 相似文献
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IntroductionIsoflavonoids are found mainly in soybeans,aprimary food source for humans and herbivores.The structure and function of isoflavonoids aresimilar to 1 7β- estradiol (1 7β- E2 ) ,and have dualeffects as both mammal oestrogenicity and anti-oestrogenicity,so they are also termed isoflavonicphytoestrogens(IPE) .It has been reported thatthese compounds can reduce blood fat,as well asthe risk of cancer and osteoporosis[1] .Genistein and daidzein are two principleisoflavonoids in soybe… 相似文献