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排序方式: 共有401条查询结果,搜索用时 15 毫秒
1.
拮抗肌对的协同控制与EMG信号的中值频率关系 总被引:4,自引:2,他引:2
探讨在持续恒力收缩时,正常人体肘关节主动肌和桔抗肌的协同作用原理与它们的表面EMG信号中值频率(Median Frequency,MF)的变化趋势,研究它们的疲劳行为。十五个正常受试者的实验数据统计结果表明,拮抗肌的SEMG/MF高于主动肌;随着收缩时间的增加,主动肌和拮抗肌的MF几乎以相同的速率下降;收缩力越大,它们的两条拟合直线之间的距离、互相关系数、下降速率也越大;关节的角度的变化对上述结论似乎没有明显的影响。这些结论对屈曲和伸展模式都成立。利用人体组织的幅度衰减特性和频率衰减特性,神经肌肉系统的“共驱动”概念对上述结果进行了讨论。 相似文献
2.
Tomomi Ikemoto Tatsuya Ito Atsuko Nishiguchi Kiminori Tomimatsu 《Tetrahedron》2004,60(48):10851-10857
The efficient synthesis of 2,3-dihydro-1-benzothiepine derivatives 4 has been developed. The intramolecular Claisen type reaction of the new products, 4-(o-formylphenylthio)butyrate 9, with alcoholate in dialkylcarbonate as a solvent afforded 4 in good yields. According to this new procedure, we have accomplished the practical preparation of CCR5 antagonist 1 as a candidate for oral HIV-1 therapy. 相似文献
3.
W 7-agarose是常用的细胞外CaM功能的拮抗剂,本实验采用荧光光谱法研究了水溶液中钙调素拮抗剂W 7-agarose与植物胞外钙调素的相互结合反应。W 7-agarose是一种将W 7-共价连接到颗粒型agarose(琼脂糖)的粒子。W 7-agarose颗粒较大且容易沉淀,静置5m in后,溶液中的荧光强度完全由游离的CaM产生。在溶液中加入W 7-agarose后,溶液中一部分CaM与其结合后沉降至荧光比色皿底部,导致溶液中CaM的荧光强度下降。由此可以确定溶液中游离CaM的浓度。根据公式lg{[Q]t(F0-F)/F0}=nlg{[Q]tF/F0} lgnK[B]t,从而计算出配位体系的结合常数和配比。研究表明:二者以摩尔比1∶1结合,其平衡常数为4.9×105。由此进一步计算了W 7-agarose对胞外钙调素的拮抗率,在拮抗剂W 7-agarose浓度达到15~20μmol/L时,拮抗率可达到90%以上,与文献报道的生物学体内实验结果一致,从分子水平上解释了W 7-agarose与CaM的结合作用。 相似文献
4.
Ho-Shen Lin Ashraff A. Rampersaud Karen Zimmerman Mitchell I. Steinberg Donald B. Boyd 《中国化学会会志》1993,40(3):273-282
A series of nonpeptide angiotensin II receptor antagonists was synthesized via palladium-assisted cross coupling of aryl stannane and cycloalkenyl triflates and subsequent alkylation of silyl-protected imidazole. Our compounds, which have a terminal five- to seven-membered cycloalkenyl ring, are compared to DuPont EXP7711, an N-[(2′-carboxybiphenylyl)methyl]imidazole, which has a terminal phenyl moiety. Physicochemical properties of the compounds, such as lipophilicity, steric bulk, conformation, and the relative spatial proximity of the 2-carboxyl and the middle phenyl, are quantitated by computational chemistry. Potency in terms of binding affinity to AT1 receptors in rat adrenal glomerulosa and rabbit aorta is maximized when the terminal ring is aromatic. 相似文献
5.
Following a freeze-thaw cycle, and the treatment of Rhodopseudomonas sphaeroides withthe nonionic detergent Lubrol PX, the permeabilized cell suspensions can be assayed directlyboth for the intracellular levels of glutamine synthetase and the state of adenylylation(i.e. the average number n of adenylylated subunits/dodecameric molecules). It seems that all components of the bicycle system are retained if cells grown with lowconcentrations of a?monia as the sole nitrogen source are used. The value of n was depend-ent upon the concentration of substrates (ATP, Pi) and allosteric effectors (ATP, gluta-mine and α-ketoglutarate) of adenylyltransferase. The value of n affected by UTP, thespecific substrate of the uridylyltransferase shows first the evidence that the bicycle cascadecontrol system studied in Escherichia coli may exist in this phototrophic bacterium. 相似文献
6.
Robert Huber 《Angewandte Chemie (International ed. in English)》1989,28(7):848-869
Aspects of intramolecular light energy and electron transfer are discussed for three protein cofactor complexes whose three-dimensional structures have been elucidated by X-ray crystallography: the light harvesting phycobilisomes of cyanobacteria, the reaction center of purple bacteria, and the blue multi-copper oxidases. A wealth of functional data is available for these systems which allows specific correlations to be made between structure and function and general conclusions to be drawn about light energy and electron transfer in biological materials. 相似文献
7.
8.
Toshio Yamanaka Mitsuru Ohkubo Fumie Takahashi Masayuki Kato 《Tetrahedron letters》2004,45(13):2843-2845
An efficient synthesis of the orally-active GpIIb/IIIa antagonist FR184764 was achieved. The key intermediate, an optically active ethynyl β-amino ester, was synthesized efficiently by utilizing a lipase catalyzed kinetic resolution step. 相似文献
9.
10.
Felicia Dragan I. Bratu Gh. Borodi Mihaela Toma A. Hernanz S. Simon Gh. Cristea R. Peschar 《Journal of inclusion phenomena and macrocyclic chemistry》2007,59(1-2):125-130
Aqueous-solution complexes of β-cyclodextrin (β-CD) with metoprolol tartrate (MET) have been analysed with 1H NMR and UV–vis spectroscopy. With 1H NMR a [1:1] stoichiometry could be established for the β-CD-MET complex while its stability constant was determined with
UV–vis spectroscopy. Powder diffraction data of a polycrystalline sample of the β-CD-MET complex show that a novel product
has been formed, likely to be a β-CD-MET [1:1] inclusion complex. Also Hyperchem MM+ molecular-dynamics results suggest an
inclusion complex and from 1H NMR data it is inferred that probably the MET is docked in the CD with the formers methoxyethyl-benzene moiety in front.
Mihaela Toma is Socrates/Erasmus student at UNED Madrid 相似文献