全文获取类型
收费全文 | 4385篇 |
免费 | 209篇 |
国内免费 | 470篇 |
专业分类
化学 | 1799篇 |
晶体学 | 27篇 |
力学 | 33篇 |
综合类 | 37篇 |
数学 | 110篇 |
物理学 | 338篇 |
综合类 | 2720篇 |
出版年
2024年 | 11篇 |
2023年 | 34篇 |
2022年 | 93篇 |
2021年 | 82篇 |
2020年 | 103篇 |
2019年 | 74篇 |
2018年 | 72篇 |
2017年 | 129篇 |
2016年 | 129篇 |
2015年 | 112篇 |
2014年 | 180篇 |
2013年 | 241篇 |
2012年 | 200篇 |
2011年 | 210篇 |
2010年 | 175篇 |
2009年 | 213篇 |
2008年 | 234篇 |
2007年 | 261篇 |
2006年 | 273篇 |
2005年 | 299篇 |
2004年 | 241篇 |
2003年 | 244篇 |
2002年 | 220篇 |
2001年 | 195篇 |
2000年 | 137篇 |
1999年 | 134篇 |
1998年 | 110篇 |
1997年 | 101篇 |
1996年 | 89篇 |
1995年 | 69篇 |
1994年 | 72篇 |
1993年 | 46篇 |
1992年 | 68篇 |
1991年 | 44篇 |
1990年 | 51篇 |
1989年 | 39篇 |
1988年 | 39篇 |
1987年 | 24篇 |
1986年 | 5篇 |
1985年 | 2篇 |
1984年 | 3篇 |
1982年 | 5篇 |
1980年 | 1篇 |
排序方式: 共有5064条查询结果,搜索用时 15 毫秒
1.
Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry 下载免费PDF全文
Dongyu Gu Yi Yang Qibin Chen Madina Habasi Jiangyu Zhao Haji Akber Aisa 《Biomedical chromatography : BMC》2015,29(4):595-603
Rupestonic acid, a potential anti‐influenza agent, is an important and characteristic compound in Artemisia rupestris L., a well‐known traditional Uighur medicine for the treatment of colds. In the present study, high‐performance liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry was used to detect and identify the metabolites in rat urine after oral administration of rupestonic acid. A total of 10 metabolites were identified or partially characterized. The structure elucidations of the metabolites were performed by comparing the changes in accurate molecular masses and fragment ions with those of the parent compound. The results showed that the main metabolites of rupestonic acid in rat urine were formed by oxidation, hydrogenation and glucuronidation. A metabolism pathway was proposed for the first time based on the characterized structures. This metabolism study can provide essential information for drug discovery, design and clinical application of rupestonic acid. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
2.
本文分析了计算机辅助教学的现状;提出了存在的若干问题;阐述了基于智能代理的计算机辅助教学系统的内容;分析了开发智能计算机辅助教学系统的发展方向. 相似文献
3.
Panagiota G. Fragouli Hermis Iatrou Nikos Hadjichristidis 《Journal of polymer science. Part A, Polymer chemistry》2004,42(3):514-519
A series of five tetrablock quarterpolymers of styrene, isoprene, dimethylsiloxane, and 2-vinylpyridine with molecular weights varying from 117 × 103 to 177 × 103 and having different compositions were synthesized. The synthesis was based on recent advances in the controlled high-vacuum anionic polymerization of hexamethylcyclotrisiloxane and on the selective linking of poly(dimethylsiloxane)lithium with the chlorosilane group of the heterofunctional linking agent chloromethylphenylethylene dimethylchlorosilane. Combined characterization results by size exclusion chromatography, membrane osmometry, and NMR spectroscopy suggested that the synthesized multiblock multicomponent polymers had a high degree of structural and compositional homogeneity. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 514–519, 2004 相似文献
4.
将自卫机制加入OOP成为AOP以提高CORBA中软件的强健性和防卫能力,在CORBA这个异构环境中,一个对象申请服务之后就需等待,如果应答迟迟不到则有可能永远等待下去,为避免这种现象的产生和蔓延,在客户和服务方的行为中加入超时机制(timeout mecha-nism)并采用利己或利他策略,使得对象可独立地根据当前环境和时间决定下一步骤,将这种在协作者失败的情况下仍能生存的对象称为自卫智能体,加入白卫智能体的CORBA称为CORBA~( ),由于智能体可在任何条件下生存,CORBA~( )可为用户提供可靠的服务,也就能实现CORBA~( )中软件构成的强健性。 相似文献
5.
在概述语义WEB的基础上,设计一个面向学习者用户网站的语义WEB体系结构,提出了多代理结构的学习支持系统中的学习者模型本体和学习者模型代理.目的是为了说明建立学习者本体及其代理对于学习者的有效学习所带来的益处. 相似文献
6.
7.
《Magnetic resonance in chemistry : MRC》2003,41(8):585-588
A novel, radical responsive MRI contrast agent based on a gadolinium chelate conjugated to a liposome through a disulfide linker was synthesized, with the aim of pursuing the in vivo mapping of radicals. The liposome was prepared by incorporating a thiol‐activated phospholipid, which was subsequently reacted with a gadolinium chelate containing a free thiol group. The long reorientational motion of the supramolecular adduct endows the paramagnetic agent with a relaxivity significantly higher than that of the free complex. The disulfide bond represents a radical‐sensitive moiety and a large decrease in contrast efficacy (T1 relaxivity) is shown upon its cleavage. A preliminary assessment of the system was made by means of in vitro gamma‐irradiation and thiol–disulfide bond exchange with dithiothreitol. Both methods showed a clear dose‐dependent decrease in T1‐relaxivity. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
8.
阳离子道路乳化沥青改性 总被引:1,自引:0,他引:1
在不改变胺化木质素为乳化剂的道路乳化沥青的筑路工艺,装备的条件下,加入复合添加剂进行改性,保留了原乳化沥青的优点,缩短了初凝时间,提高了粘聚力和抗磨性能。 相似文献
9.
为了得到高反射率的回归反射涂层产品,本项目通过大量实验,生产出最佳的粘合剂及优选出其用量,并利用扫描电镜照片进行了分析。 相似文献
10.
Suchada Suntornchashwej Dr. Khanit Suwanborirux Dr. Kazushi Koga Minoru Isobe Prof. Dr. 《化学:亚洲杂志》2007,2(1):114-122
Malyngamide X ( 1 ), the first (7R)‐lyngbic acid connected to a new tripeptide backbone, was isolated from the Thai sea hare Bursatella leachii. The gross structure of 1 was established on the basis of 1D and 2D NMR and mass spectroscopic data. Combination of the NMR spectroscopic experiments with α‐methoxy‐α‐(trifluoromethyl)phenylacetic acid esters, 2,2,2‐trifluoro‐1‐(9‐anthryl)ethanol chiral solvating agent, and molecular mechanics of 1 and the synthetic molecular fragments allowed us to determine the absolute stereochemistry of all six stereogenic centers without hydrolytic degradation of the compound. Compound 1 displayed moderate cytotoxic, antitubercular, and antimalarial properties. 相似文献